Adapted from Borer et al. 2020

Spatial self-organization during bacterial range expansion

Latest Research

  • Article
    | Open Access

    Kohno, Kobayashi, Yamamoto et al. use a recent mouse model where the affinity of the cardiac ryanodine receptor (RyR2) to Calmodulin has been enhanced through a point mutation. They show that this mutation inhibits hypertrophic signaling and improves survival after pressure-induced overload, providing insights into the mechanisms of cardiac hypertrophy

    • Michiaki Kohno
    • , Shigeki Kobayashi
    • , Takeshi Yamamoto
    • , Ryosuke Yoshitomi
    • , Toshiro Kajii
    • , Shohei Fujii
    • , Yoshihide Nakamura
    • , Takayoshi Kato
    • , Hitoshi Uchinoumi
    • , Tetsuro Oda
    • , Shinichi Okuda
    • , Kenji Watanabe
    • , Yoichi Mizukami
    •  & Masafumi Yano
  • Article
    | Open Access

    Karkman et al. explore how well available global sewage metagenomic data can predict clinical resistance prevalence using different models. A combination of sewage metagenomic data with socioeconomic factors predicts overall clinical resistance well, but still has limited ability to discriminate between resistance to different classes of antibiotics.

    • Antti Karkman
    • , Fanny Berglund
    • , Carl-Fredrik Flach
    • , Erik Kristiansson
    •  & D. G. Joakim Larsson
  • Article
    | Open Access

    Generating mice lacking protein kinase N1 (PKN1), Yasuda et al. find that PKN1 loss leads to abnormal input-nonspecific mGluR-dependent long-term depression. The authors also observe reduced glutamate uptake and immature synaptic transmission, suggesting an important role for PKN1 in synapse maturation.

    • Hiroki Yasuda
    • , Hikaru Yamamoto
    • , Kenji Hanamura
    • , Mona Mehruba
    • , Toshio Kawamata
    • , Hiromi Morisaki
    • , Masaaki Miyamoto
    • , Shinji Takada
    • , Tomoaki Shirao
    • , Yoshitaka Ono
    •  & Hideyuki Mukai
  • Article
    | Open Access

    Darwisch, von Spangenberg et al. show that ACBD5‐deficient mice exhibit elevated levels of very long‐chain fatty acids and a progressive cerebellar pathology. A complex metabolic phenotype suggests that ACBD5 with its acyl‐CoA binding and peroxisome‐ER tethering functions might contribute to the regulation of anabolic and catabolic cellular lipid pathways.

    • Warda Darwisch
    • , Marino von Spangenberg
    • , Jana Lehmann
    • , Öznur Singin
    • , Geralt Deubert
    • , Sandra Kühl
    • , Johannes Roos
    • , Heinz Horstmann
    • , Christoph Körber
    • , Simone Hoppe
    • , Hongwei Zheng
    • , Thomas Kuner
    • , Mia L. Pras-Raves
    • , Antoine H. C. van Kampen
    • , Hans R. Waterham
    • , Kathrin V. Schwarz
    • , Jürgen G. Okun
    • , Christian Schultz
    • , Frédéric M. Vaz
    •  & Markus Islinger
  • Article
    | Open Access

    Brinton, Uauy and colleagues utilize genomic data from the 10+ Wheat Genome Project to develop a useful tool for studying and generating new wheat cultivars. This framework uses advanced exploitation of wheat haplotypes to bring newfound precision and efficiency to wheat breeding.

    • Jemima Brinton
    • , Ricardo H. Ramirez-Gonzalez
    • , James Simmonds
    • , Luzie Wingen
    • , Simon Orford
    • , Simon Griffiths
    • , Georg Haberer
    • , Manuel Spannagl
    • , Sean Walkowiak
    • , Curtis Pozniak
    •  & Cristobal Uauy
  • Article
    | Open Access

    Didriksen, Nawaz, et al. identify three novel genetic risk variants for restless legs syndrome and confirm 19 out of 20 previously reported variants through a genome-wide association meta-analysis including nearly half a million individuals. Using expression QTL analysis, they also find that a subset of these loci may have a causal effect on nearby gene expression.

    • Maria Didriksen
    • , Muhammad Sulaman Nawaz
    • , Joseph Dowsett
    • , Steven Bell
    • , Christian Erikstrup
    • , Ole B. Pedersen
    • , Erik Sørensen
    • , Poul J. Jennum
    • , Kristoffer S. Burgdorf
    • , Brendan Burchell
    • , Adam S. Butterworth
    • , Nicole Soranzo
    • , David B. Rye
    • , Lynn Marie Trotti
    • , Prabhjyot Saini
    • , Lilja Stefansdottir
    • , Sigurdur H. Magnusson
    • , Gudmar Thorleifsson
    • , Thordur Sigmundsson
    • , Albert P. Sigurdsson
    • , Katja Van Den Hurk
    • , Franke Quee
    • , Michael W. T. Tanck
    • , Willem H. Ouwehand
    • , David J. Roberts
    • , Eric J. Earley
    • , Michael P. Busch
    • , Alan E. Mast
    • , Grier P. Page
    • , John Danesh
    • , Emanuele Di Angelantonio
    • , Hreinn Stefansson
    • , Henrik Ullum
    •  & Kari Stefansson

News & Comment

  • Research Highlight
    | Open Access

    The CRISPR-Cas toolbox allows genetic manipulation of cultured cells, plants and animals on the basis of simpler RNA-guided DNA recognition. It has provided breakthrough scientific opportunities to engineer desirable traits, cure genetic diseases and enable point-of-care diagnostics. A recent study by Joseph Bondy-Denomy and colleagues further equips this toolbox to cut larger chunks of DNA from a cell’s genome.

    • Anam Akhtar
  • Research Highlight
    | Open Access

    It doesn’t take much to disrupt our sleep. Whilst we are aware of environmental factors that can disturb our circadian rhythms, the precise mechanisms that control molecular time cues have remained elusive. Beesley and co-workers demonstrate that diseases associated with cytoplasmic crowding affect the sleep-wake cycle. They also pinpoint a precise time-limiting step in the trafficking of the pacemaker protein PERIOD.

    • Karli Montague-Cardoso
  • Research Highlight
    | Open Access

    While much of the work examining the ecological effects of marine warming events focuses on the magnitude and duration of elevated temperatures, a recent study from Amatzia Genin and colleagues investigates how the rate of onset of warming affects the mortality of reef fish in the Red Sea. These authors document fish mortality following two warming events with dramatic increases in temperature and report that piscivores and benthic grazers were disproportionately represented among the found carcasses. Many of these fish were infected with a bacterial pathogen following the warming event. This study points to the rate of warming increase as a critical parameter to be considered when assessing the ecological effects of marine warming events, including those for which the peak temperature is not anomalous.

    • Caitlin Karniski
  • Research Highlight
    | Open Access

    Aberrant cell signalling has been associated with a number of diseases. Belluati and coworkers make use of dual polymer nanocompartments encapsulating different enzymes, that function in unison as in a native signalling cascade. Their functionality is integrated into native cell metabolism and physiology, using substrates already present in the extracellular medium. They succeed in amplifying a natural signalling cascade and influencing cellular homoeostasis.

    • Anam Akhtar
  • Comment
    | Open Access

    Gillman and Wright propose a re-evaluation of taxonomical nomenclature to reinstate indigenous species names. These authors discuss the consideration of indigenous names for new and existing species in order to reflect the importance and precedence of indigenous knowledge in biology.

    • Len Norman Gillman
    •  & Shane Donald Wright
  • Research Highlight
    | Open Access

    Sabre-toothed carnivores are among the most famed vertebrate fossils in the world. The sabre-tooth ecomorph has been converged upon repeatedly by distantly related species throughout mammalian evolution. Lautenschlager et al. employ a range of biomechanical analyses to investigate the functional diversity of sabre-toothed skulls. Across 66 species, broad functional diversity is recovered with implications for prey specialization and niche partitioning, despite being morphologically convergent.

    • Luke R. Grinham

Collection

Mechanobiology

Marco Fritzsche

Mechanobiology

Biomechanical factors shape cellular function through influencing the structural integrity, morphology, and dynamics of cells and tissues. Here we present a collection of articles published in Communications Biology that address how mechanical forces affect biology.

Christina Karlsson Rosenthal

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