Modifying an E2 ubiquitin-conjugating enzyme with a binding domain creates an encodable strategy for driving targeted protein degradation within eukaryotic cells.

The authors performed a GWAS for pelvic organ prolapse (POP) in Japanese women, and identified WT1 as a susceptibility locus for POP in Japanese women. Transethnic GWAS meta-analysis further identified FGFR2 as an additional susceptibility locus for POP.

Phylogenomic analysis and TIRF microscopy were used to investigate the role of actin and myosin in diatom gliding. The findings support the involvement of three raphid diatom-specific myosins in force generation during cell movement.

Exploring virtual pharmacological treatments using whole-brain models and deep learning reveals improvements in disorders of consciousness models when stimulating serotonergic and opioid receptors.

Sexual dimorphism is identified in a mouse model of Friedreich’s ataxia, with males exhibiting a worse cardiac phenotype, low survival rate, as well as kidney and reproductive organ deficiencies.

Epigenetic profiling using reduced representation bisulfite sequencing provides preliminary insights into the role of DNA methylation in ageing and bovine respiratory disease in UK dairy cattle.

Cyclo(Pro-Tyr), a metabolite from Bacillus velezensis, inhibits Botrytis cinerea and Caenorhabditis elegans by disrupting membrane polarization, inducing oxidative stress, and increasing membrane fluidity. These effects trigger lipid metabolism and ROS detoxification, targeting eukaryotic membranes.

Precise odor delivery shows that moth pheromone sensitive olfactory receptor neurons are capable of very fast response to odor offset. Adaptation of the neurons on two different time scales is necessary to reproduce the response time course.

Functional neuroimaging reveals multidimensional encodings of expected posterior certainty, possibly supporting humans’ ability to anticipate the value of gathering information before making a choice.

Newly identified lncRNA TAB2-AS regulated by DNA methylation inhibits oxidative stress and apoptosis of granulosa cells of ovarian follicles, while promoting their proliferation and expediting follicular growth in mammals.

In this Q&A, Brianna Bibel, also known as the Bumbling Biochemist, talks to the journal about how social media can be harnessed to relay scientific information to other researchers, while making it fun and accessible.

Conducting research at the interface of chemistry, microbiology and marine biology, Constanze Kuhlisch reports on challenges in science due to COVID and the situation in Israel, while preparing grants to start her own research group.

Embracing the underlying principles and processes of informed proxy consent or relational autonomy consent in human ancient DNA research can transform research.

This comment reports on work done at Harvard Medical School to identify areas for improvement in research rigor, reproducibility, and responsibility in pursuit of continued research excellence.

Documentation of women’s inclusion in Indian academia and conferences by BiasWatchIndia reveals the scale of underrepresentation of women across science, technology, engineering and mathematics.