Functional in vitro assays, a 1.9 Å X-ray structure and AlphaFold2 homology models reveal how the archaeal histone variant MJ1647 from Methanocaldococcus jannaschi forms a tetrameric complex capable of DNA bridging.

Computational Sorting and Mapping of Single Cells (COSMOS) is a cloud-enabled platform that performs real-time cell imaging, analysis, and sorting using deep learning-based morphology representations.

Significant impact of post-mortem time and fixation method on immunohistochemistry performance of antibody-based staining of common markers relevant to adult neurogenesis.

A deep-learning framework leverages data from diverse populations and disentangles ancestry from the phenotype-relevant information in its representation.

Healthy adults not exhaling isoprene contain a stop mutation in the IDI2 gene, only expressed in muscle peroxisomes, suggesting that isoprene origins from muscular lipolytic cholesterol metabolism.

Infusing rats with an ultradian pattern of corticosterone, either in-phase or out-of-phase with lighting cues, has revealed how circadian misalignment induces dysregulated neuropeptide gene expression and disordered feeding behaviour.

A proof of principle approach redirects an anti-IL-1b antibody to bind the otherwise unrelated antigen, IL-17A, highlighting the plasticity of antibody scaffolds that could be manipulated for alternative binding or function.

POT1a is crucial for osteogenic-differentiation from mesenchymal stem cells (MSCs), and the ability to support B-lymphopoiesis is diminished in bone marrow microenvironments with POT1a deletion in MSCs

The development of a kidney organoid model from induced pluripotent stem cells (iPSCs) recapitulates collagen composition from mild and severe cases of Alport syndrome, establishing a kidney organoid model aiding drug discovery.

Structural studies reveal a regulatory mechanism of the human AAA+ histone chaperone, ATAD2, whereby ATAD2 auto-inhibition is relieved by histone substrate binding.

Analysis of the association between Altmetric scores and the gender of first and last authors of articles published in top cardiovascular research journals shows that women receive on average less attention for their work.

Dr. Chris Wallace is a Wellcome Trust Senior Research Fellow, Director of Research, and Principal Investigator in the Department of Medicine and a Programme Leader in the MRC Biostatistics Unit (BSU) at the University of Cambridge. Dr. Guillermo Reales is a postdoctoral researcher in Dr. Wallace’s group, where he recently co-authored a Comment evaluating the impact of sharing summary statistics on average citation rates of genome-wide association studies (GWASs). In this Q&A, we discussed the inspiration for their recent analysis on GWAS summary statistics, the importance of open data, and potential barriers or paths to data sharing in genomics.

Although liquid-liquid phase separation (LLPS) has been extensively studied in various cellular and organismal contexts, the link between functional influence of a genetic mutation and LLPS with respect to human diseases is poorly understood. A recent article by Mensah et al. looks at a rare genetic disease to identify a frameshift mutation, which triggered aberrant phase separation and nucleolar dysregulation, linking genetic variants to a dysregulation of biomolecular condensates.

March 31st marks Transgender Day of Visibility, an opportunity to celebrate and elevate the achievements of the transgender community. As part of our annual celebration of Transgender Day of Visibility, we reached out to Leland Graber and Dr. Ezra Kottler, two early-career transgender biologists who shared their own experiences and perspectives on improving support systems for the transgender research community.

We present a checklist to improve the reliability and reproducibility of molecular dynamics simulations and related methods.

Although we have come a long way in breaking down the stigma surrounding mental health conditions, we still have a long way to go. Here we speak to Dr Anna Schueth - a postdoc and passionate advocate whose blogs and other efforts are leading the way in changing academia towards a direction that will allow everyone to thrive as their authentic selves and to get the support they need.