The emergence of the plague pathogen throughout history is investigated using molecular clock modelling and phylogenetic analyses.

An ensemble deep learning model (EDLM)-based protein-protein interaction (PPI) site identification method (EDLMPPI) accurately predicts PPIs through protein language models and outperforms state-of-the-art methods on multiple benchmark sets.

A newly discovered osteological correlate for structures associated with ventilatory muscle attachment indicates a deep evolutionary history of respiratory innovation within Archosauria.

Signatures associated with COVID-19 disease severity are studied, primarily using machine learning models for classification on the basis of TCR repertoire analysis and combining such data/analysis with single cell transcriptomic data.

A screen for germination of Clostridium novyi-NT spores reveals that germinant sensing of this tumor-destructive anaerobic bacterium is stereoflexible for valine and its analogs and identifies co-germinants to improve germination efficacy in tumors.

In aggressive bladder cancer cells, the transcription factor EB is activated, leading to increased endosomal phosphatidylinositol-3-phosphate levels and lysosome dispersion to the cells’ periphery.

The study of the role of circRNA432 in a sea cucumber expands our knowledge about the relationship between circRNA and miRNA in marine invertebrates and highlights the functional links between the non-coding RNA and the pathogen-induced phagocytosis.

Connectome harmonic decomposition analysis reveals how neuromodulation and the network architecture of the human connectome jointly shape consciousness and distributed functional activation across scales.

An analysis of eye movements and EEG activity during a smooth pursuit eye movement task suggests that the process of reliability-based optimal information integration occurs in sensorimotor behaviors.

A HEK293 cell line lacking all Gαi subunits is generated which enables the measurement of coupling between a GPCR and individual Gαi subunits upon transient re-expression of a specific Gαi subunit.

A review of citation rates from genomic studies in the GWAS Catalog suggests that sharing summary statistics results, on average, in ~81.8% more citations, highlighting a benefit of publicly sharing GWAS summary statistics.

Cilia assembly and function require intraflagellar transport (IFT), a mechanism that uses “trains” to transport cargoes into and out of cilia. While much has been learned about IFT in the past decades, IFT train assembly, loading of cargo and transport regulation have remained poorly understood. In a recent study, Hesketh, Mukhopadhyay and colleagues obtained the complete structure of the IFT-A complex, a key element of IFT trains. By modelling IFT-A into anterograde trains and performing structure-guided mutagenesis, the authors uncover how the IFT-A complex polymerizes and forms carriages to accomplish its distinctive functions.

We reflect on how far we have come while looking forward to the next phase of our journey.

Recent structures of DNA-bound bacterial and phage recombinases provide insights into homologous recombination and suggest relation to the eukaryotic Rad52 and identification of a Rad52 single strand annealing protein (SSAP) superfamily.

The BIL1/BZR1 transcription factor is known to regulate transcriptional responses to the brassinosteroid class of phytohormones by directly recognizing short cis regulatory elements in promoters. A new study by Shohei Nosaki, Nobutaka Mitsuda, and colleagues published in Nature Plants indicates that binding of this transcription factor is additionally affected by nucleobases that influence DNA shape but are not directly contacted by BIL1/BZR1.

To commemorate LGBTQIA+ STEM Day this year, we reached out to faculty in institutional and national leadership roles to discuss their academic journeys, the importance of having queer role models and ways to better support LGQTBIA+ researchers.