Female Uranotaenia sapphirina mosquito feeding on a leech. Image credit: Lawrence Reeves

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  • Article | | open

    Ekaterina Osmekhina et al. report a microfluidic device that allows complete control over growth and communication via quorum sensing between bacterial populations separated by a thin nano-cellulose filter. This enables the functionalization of multicellular populations, a strategy that could be used to construct complex genetic regulatory mechanisms

    • Ekaterina Osmekhina
    • , Christopher Jonkergouw
    • , Georg Schmidt
    • , Farzin Jahangiri
    • , Ville Jokinen
    • , Sami Franssila
    •  & Markus B. Linder
  • Article | | open

    Ikuo Ogiwara et al. find that nonsense mutations in the gene coding for the voltage-gated sodium channel Nav1.2, SCN2A, cause absence-like seizures in mice. They also find that Nav1.2 haplodeficiency in excitatory, but not in inhibitory, neurons contributes to epileptogenesis.

    • Ikuo Ogiwara
    • , Hiroyuki Miyamoto
    • , Tetsuya Tatsukawa
    • , Tetsushi Yamagata
    • , Tojo Nakayama
    • , Nafiseh Atapour
    • , Eriko Miura
    • , Emi Mazaki
    • , Sara J. Ernst
    • , Dezhi Cao
    • , Hideyuki Ohtani
    • , Shigeyoshi Itohara
    • , Yuchio Yanagawa
    • , Mauricio Montal
    • , Michisuke Yuzaki
    • , Yushi Inoue
    • , Takao K. Hensch
    • , Jeffrey L. Noebels
    •  & Kazuhiro Yamakawa
  • Article | | open

    Pérard et al. report the structure of Francisella tularensis Fur (FtFur) with its physiological cofactor Fe2+, and show that FtFur is important for virulence. This study identifies a promoter-driven tetramer splitting mechanism that may provide insight into future antibiotics development.

    • J. Pérard
    • , S. Nader
    • , M. Levert
    • , L. Arnaud
    • , P. Carpentier
    • , C. Siebert
    • , F. Blanquet
    • , C. Cavazza
    • , P. Renesto
    • , D. Schneider
    • , M. Maurin
    • , J. Coves
    • , S. Crouzy
    •  & I. Michaud-Soret
  • Article | | open

    Huanle Liu et al. report draft genomes of two Symbiodinium species, one from the most dominant type of symbionts in reef-building corals. They find evidence of positive selection in genes related to stress response, meiosis and other traits required for forming successful symbiotic relationships.

    • Huanle Liu
    • , Timothy G. Stephens
    • , Raúl A. González-Pech
    • , Victor H. Beltran
    • , Bruno Lapeyre
    • , Pim Bongaerts
    • , Ira Cooke
    • , Manuel Aranda
    • , David G. Bourne
    • , Sylvain Forêt
    • , David J. Miller
    • , Madeleine J. H. van Oppen
    • , Christian R. Voolstra
    • , Mark A. Ragan
    •  & Cheong Xin Chan
  • Article | | open

    Lawrence Reeves et al. report evidence that adult females of the mosquito species Uranotaenia sapphirina feed primarily on annelid hosts. This is the first known example of a mosquito species that specializes on invertebrate blood and suggests that mosquito host use patterns are more diverse than previously recognized.

    • Lawrence E. Reeves
    • , Chris J. Holderman
    • , Erik M. Blosser
    • , Jennifer L. Gillett-Kaufman
    • , Akito Y. Kawahara
    • , Phillip E. Kaufman
    •  & Nathan D. Burkett-Cadena

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