Focus

Focus on NCB 5th Anniversary




Nature Cell Biology has just turned five, and you will find yourself reading the 61st issue this month.

Below we have assembled a collection of striking papers from our pages across the years, representing many of the subject areas covered by the journal. Each paper has had a significant impact on cell biology research, and often beyond. We think that we have selected a fair representation of what Nature Cell Biology is all about: selection of the best and the most rigorous work from the broad remit of cell biology and molecular biology.

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2003

Activation of the interferon system by short-interfering RNAs

Sledz CA, Holko M, de Veer MJ, Silverman RH, Williams BRG
Nature Cell Biology 5, 834–839 (2003)
Abstract |  Full Text

Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation

Haglund K, Sigismund S, Polo S, Szymkiewicz I, Di Fiore PP, Dikic I
Nature Cell Biology 5, 461–466 (2003)
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2002

Direct coupling of the cell cycle and cell death machinery by E2F

Nahle Z, Polakoff J, Davuluri RV, McCurrach ME, Jacobson MD, Narita M, Zhang MQ, Lazebnik Y, Bar-Sagi D, Lowe SW
Nature Cell Biology 4, 859–864 (2002)
Abstract |  Full Text

Imaging actin and dynamin recruitment during invagination of single clathrin-coated pits

Merrifield CJ, Feldman ME, Wan L, Almers W
Nature Cell Biology 4, 691–698 (2002)
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TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

Inoki K, Li Y, Zhu TQ, Wu J, Guan KL
Nature Cell Biology 4, 648–657 (2002)
Abstract |  Full Text

Molecular interpretation of ERK signal duration by immediate early gene products

Murphy LO, Smith S, Chen RH, Fingar DC, Blenis J
Nature Cell Biology 4, 556–564 (2002)
Abstract |  Full Text

Polycystin-2 is an intracellular calcium release channel

Koulen P, Cai YQ, Geng L, Maeda Y, Nishimura S, Witzgall R, Ehrlich BE, Somlo S
Nature Cell Biology 4, 191–197 (2002)
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Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi

Gervais FG, Singaraja R, Xanthoudakis S, Gutekunst CA, Leavitt BR, Metzler M, Hackam AS, Tam J, Vaillancourt JP, Houtzager V, Rasper DM, Roy S, Hayden MR, Nicholson DW
Nature Cell Biology 4, 95–105 (2002)
Abstract |  Full Text

The planar cell-polarity gene stbm regulates cell behaviour and cell fate in vertebrate embryos

Park M, Moon RT
Nature Cell Biology 4, 20–25 (2002)
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Formins direct Arp2/3-independent actin filament assembly to polarize cell growth in yeast

Evangelista M, Pruyne D, Amberg DC, Boone C, Bretscher A
Nature Cell Biology 4, 32–41 (2002)
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2001

Nicastrin is required for Presenilin-mediated transmembrane cleavage in Drosophila

Chung HM, Struhl G
Nature Cell Biology 3, 1129–1132 (2001)
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A role for the Adenomatous Polyposis Coli protein in chromosome segregation

Kaplan KB, Burds AA, Swedlow JR, Bekir SS, Sorger PK, Nathke IS
Nature Cell Biology 3, 429–432 (2001)
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TGFβ influences Myc, Miz-1 and Smad to control the CDK inhibitor p15INK4b

Seoane J, Pouponnot C, Staller P, Schader M, Eilers M, Massague J
Nature Cell Biology 3, 400–408 (2001)
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2000

A role for the lissencephaly gene LIS1 in mitosis and cytoplasmic dynein function

Faulkner NE, Dujardin DL, Tai CY, Vaughan KT, O'Connell CB, Wangs YL, Vallee RB
Nature Cell Biology 2, 784–791 (2000)
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Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome

Beere HM, Wolf BB, Cain K, Mosser DD, Mahboubi A, Kuwana T, Tailor P, Morimoto RI, Cohen GM, Green DR
Nature Cell Biology 2, 469–475 (2000)
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FAK integrates growth-factor and integrin signals to promote cell migration

Sieg DJ, Hauck CR, Ilic D, Klingbeil CK, Schaefer E, Damsky CH, Schlaepfer DD
Nature Cell Biology 2, 249–256 (2000)
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1999

SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

Carrano AC, Eytan E, Hershko A, Pagano M
Nature Cell Biology 1, 193–199 (1999)
Abstract |  Full Text