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CELIAC SPRUE AND MUCOSAL IMMUNITY
Celiac disease is an intestinal inflammatory disorder that occurs in genetically predisposed individuals and causes intolerance to wheat protein gluten and related proteins (prolamines) that are contained in barley and rye. Histologically, the small bowel mucosa in celiac disease shows villous atrophy (lost of villi), crypt hyperplasia and lymphocyte infiltration. To allow better understand the histological damage that occurs during mucosal changes Marsh proposed a series of stages to aid diagnostics: Marsh I represents lymphocytic enteritis, Marsh II represents lymphocytic enteritis with crypt hyperplasia, and Marsh III represents partial (a), subtotal (b) and total (c) villous atrophy. These changes are accompanied by a gradual increase in the number of T cells and activation of immunoregulatory counteractions in the diseased mucosa. The March 2011 special issue on celiac sprue and mucosal immunity presents some of the latest advances in celiac disease diagnostics; the web focus further expands our understanding of this inflammatory disorder through a collection of recent articles from across Springer Nature.
Reviews
Tissue-mediated control of immunopathology in coeliac disease
Bana Jabri & Ludvig M. Sollid
Nature Reviews Immunology 9, 858 - 870 doi:10.1038/nri2670
The spectrum of celiac disease: epidemiology, clinical aspects and treatment
Greetje J. Tack, Wieke H. M. Verbeek, Marco W. J. Schreurs & Chris J. J. Mulder
Nature Reviews Gastroenterology and Hepatology 7, 204 - 213 doi:10.1038/nrgastro.2010.23
Mortality in celiac disease
Federico Biagi & Gino R. Corazza
Nature Reviews Gastroenterology and Hepatology 7, 158 - 162 doi:10.1038/nrgastro.2010.2
Emerging technologies in upper gastrointestinal endoscopy and celiac disease
Nature Clinical Practice Gastroenterology & Hepatology 6, 47 - 56 doi:10.1038/ncpgasthep1298
Celiac disease in the elderly
Nature Clinical Practice Gastroenterology & Hepatology 5, 697 - 706 doi:10.1038/ncpgasthep1281
Case Studies
Treatment of postmenopausal osteoporosis in a patient with celiac disease
JoAnn V. Pinkerton, Alan C. Dalkin, Sheila E. Crowe, Barbara B. Wilson & Edward B. Stelow
Nature Reviews Endocrinology 6, 167 - 171 doi:10.1038/nrendo.2009.272
A case of celiac disease mimicking amyotrophic lateral sclerosis
Martin R Turner, Gurjit Chohan, Gerardine Quaghebeur, Richard CD Greenhall, Marios Hadjivassiliou & Kevin Talbot
Nature Clinical Practice Neurology 3, 581 - 584 doi:10.1038/ncpneuro0631
A case of sequential development of celiac disease and ulcerative colitis
William Dickey
Nature Clinical Practice Gastroenterology & Hepatology 4, 463 - 467 doi:10.1038/ncpgasthep0897
Articles
Differences in the risk of celiac disease associated with HLA-DQ2.5 or HLA-DQ2.2 are related to sustained gluten antigen presentation
Lars-Egil Fallang, Elin Bergseng, Kinya Hotta, Axel Berg-Larsen, Chu-Young Kim & Ludvig M Sollid
Nature Immunology 10, 1096 - 1101 doi:10.1038/ni.1780
Multiple common variants for celiac disease influencing immune gene expression
Patrick C A Dubois, Gosia Trynka, Lude Franke, Karen A Hunt, Jihane Romanos, Alessandra Curtotti, Alexandra Zhernakova, Graham A R Heap, Róza Ádány, Arpo Aromaa, Maria Teresa Bardella, Leonard H van den Berg, Nicholas A Bockett, Emilio G de la Concha, Bárbara Dema, Rudolf S N Fehrmann, Miguel Fernández-Arquero, Szilvia Fiatal, Elvira Grandone, Peter M Green, Harry J M Groen, Rhian Gwilliam, Roderick H J Houwen, Sarah E Hunt, Katri Kaukinen, Dermot Kelleher, Ilma Korponay-Szabo, Kalle Kurppa, Padraic MacMathuna, Markku Mäki, Maria Cristina Mazzilli, Owen T McCann, M Luisa Mearin, Charles A Mein, Muddassar M Mirza, Vanisha Mistry, Barbara Mora, Katherine I Morley, Chris J Mulder, Joseph A Murray, Concepción Núñez, Elvira Oosterom, Roel A Ophoff, Isabel Polanco, Leena Peltonen, Mathieu Platteel, Anna Rybak, Veikko Salomaa, Joachim J Schweizer, Maria Pia Sperandeo, Greetje J Tack, Graham Turner, Jan H Veldink, Wieke H M Verbeek, Rinse K Weersma, Victorien M Wolters, Elena Urcelay, Bozena Cukrowska, Luigi Greco, Susan L Neuhausen, Ross McManus, Donatella Barisani, Panos Deloukas, Jeffrey C Barrett, Paivi Saavalainen, Cisca Wijmenga &David A van Heel
Nature Genetics 42, 295 - 302 doi:10.1038/ng.543
Newly identified genetic risk variants for celiac disease related to the immune response
Karen A Hunt, Alexandra Zhernakova, Graham Turner, Graham A R Heap, Lude Franke, Marcel Bruinenberg, Jihane Romanos, Lotte C Dinesen, Anthony W Ryan, Davinder Panesar, Rhian Gwilliam, Fumihiko Takeuchi, William M McLaren, Geoffrey K T Holmes, Peter D Howdle, Julian R F Walters, David S Sanders, Raymond J Playford, Gosia Trynka, Chris J J Mulder, M Luisa Mearin, Wieke H M Verbeek, Valerie Trimble, Fiona M Stevens, Colm O'Morain, Nicholas P Kennedy, Dermot Kelleher, Daniel J Pennington, David P Strachan, Wendy L McArdle, Charles A Mein, Martin C Wapenaar, Panos Deloukas, Ralph McGinnis, Ross McManus, Cisca Wijmenga & David A van Heel
Nature Genetics 40, 395 - 402 doi:10.1038/ng.102
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