Focus |

20 years of cell biology

2019 marks twenty years since the launch of Nature Cell Biology. To celebrate our 20th anniversary we present a Focus of specially commissioned Review and Perspective articles that discuss topics across the diverse areas covered by the journal. These pieces are accompanied by a Collection of research articles published in Nature Cell Biology over the last two decades. Although they are not intended to be comprehensive, these commissioned pieces and research articles highlight the rich history and diverse scope of the journal.

Focus Content

  • Nature Cell Biology | Editorial

    This year marks the twentieth anniversary of the launch of Nature Cell Biology. We take this opportunity to reflect on the progress in cell biological research and the evolution of our journal, and to celebrate the start of our third decade with a special Focus on 20 years of cell biology.

  • Nature Cell Biology | Perspective

    In this Perspective, Dekoninck and Blanpain describe the characteristics of skin epithelial stem cells, their heterogeneity, clonal dynamics, crosstalk with other cells and remarkable plasticity during wound healing.

    • Sophie Dekoninck
    •  &  Cédric Blanpain
  • Nature Cell Biology | Review Article

    This Review describes non-redundant functions of the core transcription factors that mediate the epithelial–mesenchymal transition, and discusses the conflicting results regarding their roles in this process.

    • Marc P. Stemmler
    • , Rebecca L. Eccles
    • , Simone Brabletz
    •  &  Thomas Brabletz
  • Nature Cell Biology | Review Article

    Brunet and colleagues review emerging rejuvenation strategies that could counteract ageing features, and discuss their mechanisms of action and application against human ageing.

    • Salah Mahmoudi
    • , Lucy Xu
    •  &  Anne Brunet
  • Nature Cell Biology | Review Article

    In this Review, Schermelleh et al. give an overview of current super-resolution microscopy techniques and provide guidance on how best to use them to foster biological discovery.

    • Lothar Schermelleh
    • , Alexia Ferrand
    • , Thomas Huser
    • , Christian Eggeling
    • , Markus Sauer
    • , Oliver Biehlmaier
    •  &  Gregor P. C. Drummen
  • Nature Cell Biology | Perspective

    In this Perspective, Fässler and co-authors describe current models of how integrin adhesion molecules are activated and stabilised, and the importance of forces in this process.

    • Zhiqi Sun
    • , Mercedes Costell
    •  &  Reinhard Fässler

Cell & Molecular Biology Research Papers

  • Nature Cell Biology | Resource

    Lyden and colleagues use asymmetric flow field-flow fractionation to classify nanoparticles derived from cell lines and human samples, including previously uncharacterized large, Exo-L and small, Exo-S, exosome subsets.

    • Haiying Zhang
    • , Daniela Freitas
    • , Han Sang Kim
    • , Kristina Fabijanic
    • , Zhong Li
    • , Haiyan Chen
    • , Milica Tesic Mark
    • , Henrik Molina
    • , Alberto Benito Martin
    • , Linda Bojmar
    • , Justin Fang
    • , Sham Rampersaud
    • , Ayuko Hoshino
    • , Irina Matei
    • , Candia M. Kenific
    • , Miho Nakajima
    • , Anders Peter Mutvei
    • , Pasquale Sansone
    • , Weston Buehring
    • , Huajuan Wang
    • , Juan Pablo Jimenez
    • , Leona Cohen-Gould
    • , Navid Paknejad
    • , Matthew Brendel
    • , Katia Manova-Todorova
    • , Ana Magalhães
    • , José Alexandre Ferreira
    • , Hugo Osório
    • , André M. Silva
    • , Ashish Massey
    • , Juan R. Cubillos-Ruiz
    • , Giuseppe Galletti
    • , Paraskevi Giannakakou
    • , Ana Maria Cuervo
    • , John Blenis
    • , Robert Schwartz
    • , Mary Sue Brady
    • , Héctor Peinado
    • , Jacqueline Bromberg
    • , Hiroshi Matsui
    • , Celso A. Reis
    •  &  David Lyden
  • Nature Cell Biology | Technical Report

    Li and colleagues develop a CRISPR–Cas9-based screen strategy that combines base editing and haploid embryonic stem cell technologies to identify amino acids critical for protein function in mice.

    • Qing Li
    • , Yanjing Li
    • , Suming Yang
    • , Shuo Huang
    • , Meng Yan
    • , Yifu Ding
    • , Wei Tang
    • , Xiwen Lou
    • , Qi Yin
    • , Zhanfei Sun
    • , Lei Lu
    • , Huijuan Shi
    • , Hongyan Wang
    • , Yong Chen
    •  &  Jinsong Li
  • Nature Cell Biology | Article

    Glück et al. find that the DNA-sensing component cyclic GMP-AMP synthase (cGAS) recognizes cytosolic chromatin fragments produced in senescent cells leading to STING-mediated production of SASPs, which promotes paracrine senescence.

    • Selene Glück
    • , Baptiste Guey
    • , Muhammet Fatih Gulen
    • , Katharina Wolter
    • , Tae-Won Kang
    • , Niklas Arndt Schmacke
    • , Anne Bridgeman
    • , Jan Rehwinkel
    • , Lars Zender
    •  &  Andrea Ablasser
  • Nature Cell Biology | Article

    Integrins and talin are parts of a ‘molecular clutch’ that mechanically links the actin cytoskeleton to the extracellular matrix. Elosegui-Artola et al. now reveal a tunable rigidity threshold, above which talin unfolds to mediate force transduction.

    • Alberto Elosegui-Artola
    • , Roger Oria
    • , Yunfeng Chen
    • , Anita Kosmalska
    • , Carlos Pérez-González
    • , Natalia Castro
    • , Cheng Zhu
    • , Xavier Trepat
    •  &  Pere Roca-Cusachs
  • Nature Cell Biology | Article

    Medina, Ballabio and colleagues report that calcium release from the lysosome stimulates calcineurin, which dephosphorylates and activates TFEB. These findings reveal a central role for calcium signalling in autophagy and lysosome homeostasis.

    • Diego L. Medina
    • , Simone Di Paola
    • , Ivana Peluso
    • , Andrea Armani
    • , Diego De Stefani
    • , Rossella Venditti
    • , Sandro Montefusco
    • , Anna Scotto-Rosato
    • , Carolina Prezioso
    • , Alison Forrester
    • , Carmine Settembre
    • , Wuyang Wang
    • , Qiong Gao
    • , Haoxing Xu
    • , Marco Sandri
    • , Rosario Rizzuto
    • , Maria Antonietta De Matteis
    •  &  Andrea Ballabio

Stem Cells & Development Research Papers

  • Nature Cell Biology | Resource

    Using scCOOL-seq, Li et al. simultaneously characterize the DNA methylation and chromatin accessibility of the same cell during human preimplantation development.

    • Lin Li
    • , Fan Guo
    • , Yun Gao
    • , Yixin Ren
    • , Peng Yuan
    • , Liying Yan
    • , Rong Li
    • , Ying Lian
    • , Jingyun Li
    • , Boqiang Hu
    • , Junpeng Gao
    • , Lu Wen
    • , Fuchou Tang
    •  &  Jie Qiao
  • Nature Cell Biology | Article

    Velten et al. use single-cell transcriptomics and functional data to map the early lineage commitment of human haematopoietic stem cells as a continuous process of cells passing through transitory states rather than demarcating discrete progenitors.

    • Lars Velten
    • , Simon F. Haas
    • , Simon Raffel
    • , Sandra Blaszkiewicz
    • , Saiful Islam
    • , Bianca P. Hennig
    • , Christoph Hirche
    • , Christoph Lutz
    • , Eike C. Buss
    • , Daniel Nowak
    • , Tobias Boch
    • , Wolf-Karsten Hofmann
    • , Anthony D. Ho
    • , Wolfgang Huber
    • , Andreas Trumpp
    • , Marieke A. G. Essers
    •  &  Lars M. Steinmetz
  • Nature Cell Biology | Letter

    Chen et al. generate lung bud organoids from human pluripotent stem cells that recapitulate early lung development, such as branching airway formation and early alveolar structures, which could potentially be used to model lung disease.

    • Ya-Wen Chen
    • , Sarah Xuelian Huang
    • , Ana Luisa Rodrigues Toste de Carvalho
    • , Siu-Hong Ho
    • , Mohammad Naimul Islam
    • , Stefano Volpi
    • , Luigi D. Notarangelo
    • , Michael Ciancanelli
    • , Jean-Laurent Casanova
    • , Jahar Bhattacharya
    • , Alice F. Liang
    • , Laura M. Palermo
    • , Matteo Porotto
    • , Anne Moscona
    •  &  Hans-Willem Snoeck
  • Nature Cell Biology | Article

    Park et al. study individual cell dynamics during mouse wound re-epithelialization in real time and reveal a finely orchestrated interplay between epidermal migration, directional division and differentiation.

    • Sangbum Park
    • , David G. Gonzalez
    • , Boris Guirao
    • , Jonathan D. Boucher
    • , Katie Cockburn
    • , Edward D. Marsh
    • , Kailin R. Mesa
    • , Samara Brown
    • , Panteleimon Rompolas
    • , Ann M. Haberman
    • , Yohanns Bellaïche
    •  &  Valentina Greco
  • Nature Cell Biology | Article

    Passegué and colleagues reveal that pro-inflammatory IL-1 accelerates cell division and induces PU.1-mediated differentiation of HSCs into myeloid cells, whereas chronic IL-1 exposure compromises HSC function.

    • Eric M. Pietras
    • , Cristina Mirantes-Barbeito
    • , Sarah Fong
    • , Dirk Loeffler
    • , Larisa V. Kovtonyuk
    • , SiYi Zhang
    • , Ranjani Lakshminarasimhan
    • , Chih Peng Chin
    • , José-Marc Techner
    • , Britta Will
    • , Claus Nerlov
    • , Ulrich Steidl
    • , Markus G. Manz
    • , Timm Schroeder
    •  &  Emmanuelle Passegué

Physiology & Disease Research Papers

  • Nature Cell Biology | Article

    Cancer-associated fibroblasts (CAFs) promote metastasis by creating tracks for cancer cell migration. Labernadie et al. now show that heterotypic adhesions between E-cadherin on cancer cells and N-cadherin on CAFs transmit forces to drive invasion.

    • Anna Labernadie
    • , Takuya Kato
    • , Agustí Brugués
    • , Xavier Serra-Picamal
    • , Stefanie Derzsi
    • , Esther Arwert
    • , Anne Weston
    • , Victor González-Tarragó
    • , Alberto Elosegui-Artola
    • , Lorenzo Albertazzi
    • , Jordi Alcaraz
    • , Pere Roca-Cusachs
    • , Erik Sahai
    •  &  Xavier Trepat
  • Nature Cell Biology | Article

    Aguirre-Ghiso and colleagues report that hypoxia in the primary tumour microenvironment leads to upregulation of a dormancy signature in the tumour cells that persists after their dissemination to distant sites, permitting them to evade therapy.

    • Georg Fluegen
    • , Alvaro Avivar-Valderas
    • , Yarong Wang
    • , Michael R. Padgen
    • , James K. Williams
    • , Ana Rita Nobre
    • , Veronica Calvo
    • , Julie F. Cheung
    • , Jose Javier Bravo-Cordero
    • , David Entenberg
    • , James Castracane
    • , Vladislav Verkhusha
    • , Patricia J. Keely
    • , John Condeelis
    •  &  Julio A. Aguirre-Ghiso
  • Nature Cell Biology | Article

    Yang and colleagues identify a lncRNA that controls HIF1α signalling to stabilize HIF1α under normoxic conditions, and promotes breast cancer tumorigenesis.

    • Aifu Lin
    • , Chunlai Li
    • , Zhen Xing
    • , Qingsong Hu
    • , Ke Liang
    • , Leng Han
    • , Cheng Wang
    • , David H. Hawke
    • , Shouyu Wang
    • , Yanyan Zhang
    • , Yongkun Wei
    • , Guolin Ma
    • , Peter K. Park
    • , Jianwei Zhou
    • , Yan Zhou
    • , Zhibin Hu
    • , Yubin Zhou
    • , Jeffery R. Marks
    • , Han Liang
    • , Mien-Chie Hung
    • , Chunru Lin
    •  &  Liuqing Yang
  • Nature Cell Biology | Article

    Gottlieb and colleagues demonstrate that glioblastoma cell proliferation under glutamine starvation conditions depends on the glutamine-synthetase-dependent conversion of glutamate to glutamine to fuel purine biosynthesis and cell growth.

    • Saverio Tardito
    • , Anaïs Oudin
    • , Shafiq U. Ahmed
    • , Fred Fack
    • , Olivier Keunen
    • , Liang Zheng
    • , Hrvoje Miletic
    • , Per Øystein Sakariassen
    • , Adam Weinstock
    • , Allon Wagner
    • , Susan L. Lindsay
    • , Andreas K. Hock
    • , Susan C. Barnett
    • , Eytan Ruppin
    • , Svein Harald Mørkve
    • , Morten Lund-Johansen
    • , Anthony J. Chalmers
    • , Rolf Bjerkvig
    • , Simone P. Niclou
    •  &  Eyal Gottlieb
  • Nature Cell Biology | Article

    Rodeheffer and colleagues show that a high-fat diet in mice activates Akt2 signalling in adipocyte precursors within white adipose tissue deposits, leading to their proliferation and differentiation into adipocytes, and to obesity.

    • Elise Jeffery
    • , Christopher D. Church
    • , Brandon Holtrup
    • , Laura Colman
    •  &  Matthew S. Rodeheffer
  • Nature Cell Biology | Article

    Yang and colleagues report that increased extracellular matrix stiffness promotes nuclear localization of Twist1 to drive epithelial–mesenchymal transition, cancer cell invasion and metastasis.

    • Spencer C. Wei
    • , Laurent Fattet
    • , Jeff H. Tsai
    • , Yurong Guo
    • , Vincent H. Pai
    • , Hannah E. Majeski
    • , Albert C. Chen
    • , Robert L. Sah
    • , Susan S. Taylor
    • , Adam J. Engler
    •  &  Jing Yang