Focus
Focus on Telomeres
- Focus issue:
- November 2015 Volume 22, No 11
Editorial
Focus on Telomeres
Unraveling the ends - p843
doi:10.1038/nsmb.3123
Deciphering the complexity of events at telomeres has enhanced understanding of how telomeres function to maintain genome integrity and how their dysfunction gives rise to human disease.
Full Text - Unraveling the ends | PDF (558 KB) - Unraveling the ends
Commentary
Focus on Telomeres
A DNA-hairpin model for repeat-addition processivity in telomere synthesis - pp844 - 847
Wei Yang & Young-Sam Lee
doi:10.1038/nsmb.3098
Abstract - A DNA-hairpin model for repeat-addition processivity in telomere synthesis | Full Text - A DNA-hairpin model for repeat-addition processivity in telomere synthesis | PDF (1,620 KB) - A DNA-hairpin model for repeat-addition processivity in telomere synthesis | Supplementary information
Perspectives
Focus on Telomeres
Control of telomerase action at human telomeres - pp848 - 852
Dirk Hockemeyer & Kathleen Collins
doi:10.1038/nsmb.3083
Abstract - Control of telomerase action at human telomeres | Full Text - Control of telomerase action at human telomeres | PDF (541 KB) - Control of telomerase action at human telomeres
Focus on Telomeres
TERRA and the state of the telomere - pp853 - 858
Karsten Rippe & Brian Luke
doi:10.1038/nsmb.3078
Abstract - TERRA and the state of the telomere | Full Text - TERRA and the state of the telomere | PDF (1,039 KB) - TERRA and the state of the telomere
Reviews
Focus on Telomeres
Complex interactions between the DNA-damage response and mammalian telomeres - pp859 - 866
Nausica Arnoult & Jan Karlseder
doi:10.1038/nsmb.3092
Abstract - Complex interactions between the DNA-damage response and mammalian telomeres | Full Text - Complex interactions between the DNA-damage response and mammalian telomeres | PDF (632 KB) - Complex interactions between the DNA-damage response and mammalian telomeres
Focus on Telomeres
Molecular basis of telomere dysfunction in human genetic diseases - pp867 - 874
Grzegorz Sarek, Paulina Marzec, Pol Margalef & Simon J Boulton
doi:10.1038/nsmb.3093
Abstract - Molecular basis of telomere dysfunction in human genetic diseases | Full Text - Molecular basis of telomere dysfunction in human genetic diseases | PDF (862 KB) - Molecular basis of telomere dysfunction in human genetic diseases
Focus on Telomeres
Molecular mechanisms of activity and derepression of alternative lengthening of telomeres - pp875 - 880
Hilda A Pickett & Roger R Reddel
doi:10.1038/nsmb.3106
Abstract - Molecular mechanisms of activity and derepression of alternative lengthening of telomeres | Full Text - Molecular mechanisms of activity and derepression of alternative lengthening of telomeres | PDF (665 KB) - Molecular mechanisms of activity and derepression of alternative lengthening of telomeres
Related Content
News & Views
Articles
Structural basis of template-boundary definition in Tetrahymena telomerase
Linnea I Jansson, Ben M Akiyama, Alexandra Ooms, Cheng Lu, Seth M Rubin and Michael D Stone
Nature Structural & Molecular Biology 22: 883-888; Published online, 05 October 2015; doi:10.1038/nsmb.3101
Structural basis for protein-RNA recognition in telomerase
Jing Huang, Andrew F Brown, Jian Wu, Jing Xue, Christopher J Bley, Dustin P Rand, Lijie Wu, Rongguang Zhang, Julian J-L Chen and Ming Lei
Nature Structural & Molecular Biology 21: 507-512; Published online, 04 May 2014; doi:10.1038/nsmb.2819
Rapid induction of alternative lengthening of telomeres by depletion of the histone chaperone ASF1
Roderick J O'Sullivan, Nausica Arnoult, Daniel H Lackner, Liana Oganesian, Candy Haggblom, Armelle Corpet, Genevieve Almouzni and Jan Karlseder
Nature Structural & Molecular Biology 21: 167-174; Published online, 12 January 2014; doi:10.1038/nsmb.2754
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