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HELPER T CELL SUBSETS: DIFFERENTIATION AND FUNCTION
- Special issue:
- May 2010 Volume 7, No 3
Helper T cell heterogeneity was discovered two decades ago, initially with the designation of Th1 and Th2 cells, which are involved in immunity against intracellular and extracellular pathogens, respectively. Several years ago a third lineage was identified as the Th17 cells and several novel T cell subsets have since been found, including Treg and Tfh cells. The collection of articles presented in the May special issue and accompanying web focus summarize our understanding of the development and function of the T cell subsets in immunity and immune diseases.
MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis
Changsheng Du, Chang Liu, Jiuhong Kang, Guixian Zhao, Zhiqiang Ye, Shichao Huang, Zhenxin Li, Zhiying Wu & Gang Pei
Nature Immunology 10: 1252-1259 (18 October 2009); doi:10.1038/ni.1798
New insights into the differentiation and function of T follicular helper cells
Cecile King
Nature Reviews Immunology 9: 757-766 (November 2009); doi:10.1038/nri2644
Interplay between the TH17 and TReg cell lineages: a (co-)evolutionary perspective
Casey T Weaver & Robin D Hatton
Nature Reviews Immunology 9: 883-889 (December 2009); doi:10.1038/nri2660
The functional plasticity of T cell subsets
Jeffrey A Bluestone, Charles R Mackay, John J O'Shea & Brigitta Stockinger
Nature Reviews Immunology 9: 811-816 (7 October 2009); doi:10.1038/nri2654
(IL-)12 and 21: a new kind of help in the follicles FREE
Roza I Nurieva and Chen Dong
Immunol Cell Biol 87: 577-578 (12 November 2009); doi:10.1038/icb.2009.79
Regulation of IL-9 expression by IL-25 signaling
Pornpimon Angkasekwinai, Seon Hee Chang, Manoj Thapa, Hiroshi Watarai & Chen Dong
Nature Immunology 11: 250-256 (14 February 2010); doi:10.1038/ni.1846
Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression
Yisong Y Wan & Richard A Flavell
Nature 445: 766-770 (14 January 2007); doi:10.1038/nature05479
First paragraph | Full Text | PDF | Supplementary information
Crucial role of interleukin-7 in T helper type 17 survival and expansion in autoimmune disease
Xuebin Liu, Stewart Leung, Chunxia Wang, Zhu Tan, Ji Wang, Taylor B Guo, Lei Fang, Yonggang Zhao, Bing Wan, Xia Qin, Limin Lu, Runsheng Li, Heng Pan, Mingjuan Song, Ailian Liu, Jian Hong, Hongtao Lu & Jingwu Z Zhang
Nature Medicine 16: 191-197 (10 January 2010); doi:10.1038/nm.2077
Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA
Di Yu, Andy Hee-Meng Tan, Xin Hu, Vicki Athanasopoulos, Nicholas Simpson, Diego G Silva, Andreas Hutloff, Keith M Giles, Peter J Leedman, Kong Peng Lam, Christopher C Goodnow & Carola G. Vinuesa
Nature 450: 299-303 (8 November 2007); doi:10.1038/nature06253
First paragraph | Full Text | PDF | Supplementary information
Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis
Masako Murai, Olga Turovskaya, Gisen Kim, Rajat Madan, Christopher L Karp, Hilde Cheroutre & Mitchell Kronenberg
Nature Immunology 10: 1178-1184 (27 September 2009); doi:10.1038/ni.1791
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