Encoded macrocycles

Macrocycles have attracted considerable attention as potential binders for challenging pharmaceutical targets. Attaching a chemical 'barcode' enables a chemical library containing many different macrocycles to be screened against a protein target. The identity of successful binders can then be read back at the end of the screening process. However, building libraries of encoded macrocycles, especially large libraries that are diverse in terms of their coverage of chemical space has proven difficult. A collection of articles in this focus look at different methods to create libraries of encoded peptide macrocycles and the advantages that such libraries offer for discovering protein binders.


From the archives