Focus |

Series on Stem Cell Biology

Stem cells have the unique capacity to self-renew and differentiate into a wide array of more specialized cells during development, but also to maintain homeostasis and to support tissue regeneration. Thus stem cells and their more differentiated derivatives are attractive models for studying development and disease, and represent a potential source for cell replacement therapies. Nature Cell Biology presents a series of commissioned articles that discuss recent advances, challenges and controversies in stem cell research. An accompanying online library contains research articles on this topic published in the past eighteen months by Nature Cell Biology and other Nature journals.

Content

  • Nature Cell Biology | Editorial

    Stem cell biology has emerged as one of the most exciting areas of basic and biomedical research. This month, we launch a series of specially commissioned articles that discuss recent advances and challenges in this field.

  • Nature Cell Biology | Commentary

    Yaffe and colleagues discuss the issues surrounding the authentication and quality of induced pluripotent stem cells.

    • Michael P. Yaffe
    • , Scott A. Noggle
    •  &  Susan L. Solomon
  • Nature Cell Biology | Review Article

    Barker and colleagues review the history and recent developments of organoid cultures derived from pluripotent stem cells and adult epithelia, and discuss how the technology can be used for basic research as well as translational applications.

    • Aliya Fatehullah
    • , Si Hui Tan
    •  &  Nick Barker
  • Nature Cell Biology | Perspective

    De novo generation of haematopoietic stem cells from different human pluripotent stem cell sources remains a high priority for haematology and regenerative medicine. At present, efficient derivation of functional haematopoietic stem cells with the capability for definitive in vivo engraftment and multi-lineage potential remains challenging. Here, we discuss recent progress and strategies to overcome obstacles that have thwarted past efforts. In addition, we review promising advances in the generation of mature blood lineages and the potential of induced pluripotent stem cells.

    • Lara Wahlster
    •  &  George Q. Daley
  • Nature Cell Biology | Perspective

    Visvader and Clevers discuss how stem cells from different tissues, such as the intestine, mammary gland and skeletal muscle, follow different strategies and hierarchies to maintain their complex, tissue-specific balance.

    • Jane E. Visvader
    •  &  Hans Clevers

From the archives

  • Nature Cell Biology | Article

    Nerlov and colleagues show that expression of mKitL by cortical vascular endothelial cells is important for DN1 progenitor maintenance, whereas expression of mKitL by cortical thymic epithelial cells is required for maintaining DN2 progenitor cells.

    • Mario Buono
    • , Raffaella Facchini
    • , Sahoko Matsuoka
    • , Supat Thongjuea
    • , Dominique Waithe
    • , Tiago C. Luis
    • , Alice Giustacchini
    • , Peter Besmer
    • , Adam J. Mead
    • , Sten Eirik W. Jacobsen
    •  &  Claus Nerlov
  • Nature Cell Biology | Article

    Nowell et al. report that chronic inflammation of the corneal epithelium activates β-catenin signalling through YAP/TAZ-dependent mechanotransduction, leading to epidermal differentiation on the ocular surface and corneal squamous cell metaplasia.

    • Craig S. Nowell
    • , Pascal D. Odermatt
    • , Luca Azzolin
    • , Sylke Hohnel
    • , Erwin F. Wagner
    • , Georg E. Fantner
    • , Matthias P. Lutolf
    • , Yann Barrandon
    • , Stefano Piccolo
    •  &  Freddy Radtke
  • Nature Cell Biology | Article

    Lacaud and colleagues show that the GFI1 transcriptional repressors are required for endothelial-to-haematopoietic transition in the aorta–gonad–mesonephros region of the mouse embryo by inhibiting the endothelial gene expression program via LSD1.

    • Roshana Thambyrajah
    • , Milena Mazan
    • , Rahima Patel
    • , Victoria Moignard
    • , Monika Stefanska
    • , Elli Marinopoulou
    • , Yaoyong Li
    • , Christophe Lancrin
    • , Thomas Clapes
    • , Tarik Möröy
    • , Catherine Robin
    • , Crispin Miller
    • , Shaun Cowley
    • , Berthold Göttgens
    • , Valerie Kouskoff
    •  &  Georges Lacaud
  • Nature Cell Biology | Article

    By comparing the metabolomes, transcriptomes and epigenomes of human pluripotent stem cell lines, Sperber et al. show that interplay between the metabolome and histone modifications drives the metabolic switch from naive to primed pluripotency.

    • Henrik Sperber
    • , Julie Mathieu
    • , Yuliang Wang
    • , Amy Ferreccio
    • , Jennifer Hesson
    • , Zhuojin Xu
    • , Karin A. Fischer
    • , Arikketh Devi
    • , Damien Detraux
    • , Haiwei Gu
    • , Stephanie L. Battle
    • , Megan Showalter
    • , Cristina Valensisi
    • , Jason H. Bielas
    • , Nolan G. Ericson
    • , Lilyana Margaretha
    • , Aaron M. Robitaille
    • , Daciana Margineantu
    • , Oliver Fiehn
    • , David Hockenbery
    • , C. Anthony Blau
    • , Daniel Raftery
    • , Adam A. Margolin
    • , R. David Hawkins
    • , Randall T. Moon
    • , Carol B. Ware
    •  &  Hannele Ruohola-Baker
  • Nature | Article

    Drosophila intestinal stem cells (ISCs) respond to changes in diet, particularly L-glutamate levels, by modulating Ca2+ signalling to adapt their proliferation rate; furthermore, Ca2+ is shown to be central to the response of ISCs to a wide range of dietary and stress stimuli.

    • Hansong Deng
    • , Akos A. Gerencser
    •  &  Heinrich Jasper
  • Nature | Article

    RNA interference screens were used to identify chromatin-associated factors that impede reprogramming of somatic cells into iPS cells; suppression of the chromatin assembly factor CAF-1 enhances the generation of iPS cells by rendering chromatin more accessible to pluripotency transcription factors.

    • Sihem Cheloufi
    • , Ulrich Elling
    • , Barbara Hopfgartner
    • , Youngsook L. Jung
    • , Jernej Murn
    • , Maria Ninova
    • , Maria Hubmann
    • , Aimee I. Badeaux
    • , Cheen Euong Ang
    • , Danielle Tenen
    • , Daniel J. Wesche
    • , Nadezhda Abazova
    • , Max Hogue
    • , Nilgun Tasdemir
    • , Justin Brumbaugh
    • , Philipp Rathert
    • , Julian Jude
    • , Francesco Ferrari
    • , Andres Blanco
    • , Michaela Fellner
    • , Daniel Wenzel
    • , Marietta Zinner
    • , Simon E. Vidal
    • , Oliver Bell
    • , Matthias Stadtfeld
    • , Howard Y. Chang
    • , Genevieve Almouzni
    • , Scott W. Lowe
    • , John Rinn
    • , Marius Wernig
    • , Alexei Aravin
    • , Yang Shi
    • , Peter J. Park
    • , Josef M. Penninger
    • , Johannes Zuber
    •  &  Konrad Hochedlinger