Focus

Focus on Natural Killer Cells

Five specially commissioned articles focus on the differentiation, responsiveness and biological roles of natural killer cells. The focus is available free to registrants for six months.

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Editorial

Focus on Natural Killer Cells

Outside the box p471

doi:10.1038/ni0508-471

This Focus on natural killer cells aims to highlight what is currently known and what remains to be understood about these important innate immune cells.


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Overview

Focus on Natural Killer Cells

Natural killer cells: diversity in search of a niche pp473 - 475

James P Di Santo

doi:10.1038/ni.f.201


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Essay

Focus on Natural Killer Cells

Natural killer cell recognition of missing self pp477 - 480

Klas Kärre

doi:10.1038/ni0508-477

The idea that NK cells can distinguish aberrant cells by recognizing 'absence of the expected', rather than 'presence of the unexpected' emerged more than 25 years ago. Klas Kärre recapitulates how the idea took shape, and the first five years of experimental work to test its general predictions.


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Perspectives

Focus on Natural Killer Cells

Mistaken notions about natural killer cells pp481 - 485

Wayne M Yokoyama

doi:10.1038/ni1583


Focus on Natural Killer Cells

Natural killer cell–directed therapies: moving from unexpected results to successful strategies pp486 - 494

Magali Terme, Evelyn Ullrich, Nicolas F Delahaye, Nathalie Chaput & Laurence Zitvogel

doi:10.1038/ni1580


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Reviews

Focus on Natural Killer Cells

Up on the tightrope: natural killer cell activation and inhibition pp495 - 502

Lewis L Lanier

doi:10.1038/ni1581


Focus on Natural Killer Cells

Functions of natural killer cells pp503 - 510

Eric Vivier, Elena Tomasello, Myriam Baratin, Thierry Walzer & Sophie Ugolini

doi:10.1038/ni1582


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Research Highlights

Focus on Natural Killer Cells

Research Highlights p511

doi:10.1038/ni0508-511


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