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Organic Chemistry and Chemical Biology

Giovanni Bottari: organic chemistry.

Julia Eckhoff: chemical biology, medicinal and prebiotic chemistry.

Johannes Kreutzer: soft matter and organic functional materials. 

Prabhjot Saini: polymers and hydrogels.

Welcome to the Nature Communications Editors’ Highlights webpage on organic chemistry and chemical biology. Each month our editors select a small number of Articles recently published in Nature Communications that they believe are particularly interesting or important.

The aim is to provide a snapshot of some of the most exciting work published in the area of organic chemistry and chemical biology at Nature Communications.

Make sure to check the Editors' Highlights page each month for new featured articles.

The depsipeptide Lysocin E has antibacterial activity against methicillin-resistant Staphylococcus aureus. Here, the authors developed a high-throughput one-bead-on-compound method for the synthesis and screening lysocin E derivatives, with several hits being more active than the parent compound.

Article | Open Access | | Nature Communications

Single-site labelling of proteins is desirable, e.g., for analytical purposes. Here, the authors developed a method in which they use an aldol-type reaction to modify proteins at N-terminal glycine residues in an efficient and selective manner, which is also applicable to cell lysates.

Article | Open Access | | Nature Communications

The reduction of 2-naphtoyl-CoA to 5,6 dihydro-2-naphtoyl-CoA by 2-naphtoyl-CoA reductase is below the negative redox limit usually encountered in biological hydride transfer. Here, via X-ray crystallography and spectroscopic analysis, the authors elucidated the mechanism behind this.

Article | Open Access | | Nature Communications

Membraneless compartments have been theorized to be prebiotic micro-compartments as they spontaneously encapsulate RNA and proteins. Here, the authors report membraneless compartments can enhance RNA chemistries, affecting template directed RNA polymerization and stimulating nucleic acid enzymes.

Article | Open Access | | Nature Communications