Focus |

Organic Chemistry and Chemical Biology

Giovanni Bottari: organic chemistry.

Majda Bratovič: chemical biology, medicinal, protein and prebiotic chemistry.

Johannes Kreutzer: soft matter and organic functional materials. 

Prabhjot Saini: polymers and hydrogels.

Welcome to the Nature Communications Editors’ Highlights webpage on organic chemistry and chemical biology. Each month our editors select a small number of Articles recently published in Nature Communications that they believe are particularly interesting or important.

The aim is to provide a snapshot of some of the most exciting work published in the area of organic chemistry and chemical biology at Nature Communications.

Make sure to check the Editors' Highlights page each month for new featured articles.

The feasibility of molecular assemblers as a device to control chemical reactions by positioning molecules with atomic precision is a matter of debate in the literature. Here the authors describe of a rudimentary synthetic molecular assembler, supramolecular aggregate of bifunctional surfactants produced by the reaction of two phase-separated reactants that produces polymers.

Article | Open Access | | Nature Communications

Additive manufacturing processing requirements pose restrictions on materials and joining chemically dissimilar components. Here the authors use silicone double networks that participate in orthogonal crosslinking mechanisms for independent control of the shape forming process and final mechanical properties.

Article | Open Access | | Nature Communications

Connecting molecular-level phenomena to larger scales and molecular systems that resemble living systems remains a considerable challenge in supramolecular chemistry. Here, the authors report different self-assembly patterns in a porphyrin structure which can form – depending on the concentration - spirals or toroids.

Article | Open Access | | Nature Communications

Using fluorescence lifetime as the readout modality offers more reproducible and quantitative outputs compared to conventional fluorescent barcoding, being independent of sample concentration and measurement methods. Here, the authors design a photo-switchable nanogel exhibiting variable fluorescence lifetime, and demonstrate visual mapping by using fluorescence lifetime imaging microscopy on a sub-cellular scale.

Article | Open Access | | Nature Communications

Development of porous proton-transporting materials combining stability and high performance has remained a challenge. Here, the authors report a stable covalent organic framework with excellent proton conductivity in which nitrogen sites on pore walls confine and stabilize a H3PO4 network in the channels via hydrogen-bonding interactions.

Article | Open Access | | Nature Communications

Color changes by external stimuli, so-called chromism, have been intensively studied to develop smart materials due to the stimulus-responsiveness of chromic materials. Here the authors demonstrate luminescent chromism during a mechanically controllable phase transition in a luminescent organosuperelastic crystal.

Article | Open Access | | Nature Communications

Conducting polymers are promising materials for diverse applications but the fabrication of conducting polymers mostly relies on conventional fabrication techniques. Here the authors introduce a high performance 3D printable conducting polymer ink to take full advantage of advanced 3D printing.

Article | Open Access | | Nature Communications

Many reagents have been developed for cysteine-specific protein modification. However, few of them allow for multi-functionalization of a single Cys residue and disulfide bridging bioconjugation. Here the authors report 3-bromo-5-methylene pyrrolones as a simple, robust and versatile class of reagents for cysteine-specific protein modification.

Article | Open Access | | Nature Communications