Focus on protein dynamics
In this issue - pv
doi:10.1038/nchembio.254
Focus
Focus on Protein Dynamics
- Focus issue:
- Novust 2009 Volume 5, No 11
This special issue contains a collection of articles that discuss our current understanding of protein dynamics and the methods used to study the dynamics of individual proteins and their interactions with the larger biological systems where they function.
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Editorial
Focus on protein dynamics
Eyes wide open - p773
doi:10.1038/nchembio.258
Understanding how proteins function in isolation and in their native context requires a merging of molecular-level techniques that explore the interplay of protein structure and dynamics.
Full Text - Closing in on catalysis | PDF (108 KB) - Eyes wide open
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Commentaries
Focus on protein dynamics
Post-reductionist protein science, or putting Humpty Dumpty back together again - pp774 - 777
Lila M Gierasch & Anne Gershenson
doi:10.1038/nchembio.241
In their native environments, proteins perform their biological roles in highly concentrated viscous solutions and in complex networks with numerous partners. Yet for many years, the normal practice has been to purify a protein of interest in order to characterize its structural and functional properties. In this Commentary, we discuss how protein scientists are now tackling the theoretical and methodological challenges of studying proteins in their physiological context.
Full Text - The far reaches of enzymology | PDF (1,158 KB) - Post-reductionist protein science, or putting Humpty Dumpty back together again
Focus on protein dynamics
The nanny model for IDPs - pp778 - 788
Peter Tsvetkov, Nina Reuven & Yosef Shaul
doi:10.1038/nchembio.233
Intrinsically disordered proteins (IDPs) are subject to ubiquitin-independent degradation, a default and passive process. We describe here a model wherein a group of 'nanny' proteins function to protect newly synthesized IDPs from degradation by default, thereby insuring their maturation into important regulatory molecules.
Full Text - The nanny model for IDPs | PDF (723 KB) - The nanny model for IDPs
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Perspective
Focus on protein dynamics
The role of dynamic conformational ensembles in biomolecular recognition - pp789 - 796
David D Boehr, Ruth Nussinov & Peter E Wright
doi:10.1038/nchembio.232
Abstract - The role of dynamic conformational ensembles in biomolecular recognition | Full Text - The role of dynamic conformational ensembles in biomolecular recognition | PDF (568 KB) - The role of dynamic conformational ensembles in biomolecular recognition
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Reviews
Focus on protein dynamics
Computer-aided design of functional protein interactions - pp797 - 807
Daniel J Mandell & Tanja Kortemme
doi:10.1038/nchembio.251
Abstract - Computer-aided design of functional protein interactions | Full Text - Computer-aided design of functional protein interactions | PDF (876 KB) - Computer-aided design of functional protein interactions
Focus on protein dynamics
NMR spectroscopy brings invisible protein states into focus - pp808 - 814
Andrew J Baldwin & Lewis E Kay
doi:10.1038/nchembio.238
Abstract - NMR spectroscopy brings invisible protein states into focus | Full Text - NMR spectroscopy brings invisible protein states into focus | PDF (916 KB) - NMR spectroscopy brings invisible protein states into focus
Focus on protein dynamics
Targeting proteins for degradation - pp815 - 822
Erin K Schrader, Kristine G Harstad & Andreas Matouschek
doi:10.1038/nchembio.250
Abstract - Targeting proteins for degradation | Full Text - Targeting proteins for degradation | PDF (1,028 KB) - Targeting proteins for degradation
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