Focus on biological catalysis
The far reaches of enzymology - pp516 - 520
Jesse G Zalatan
&
Daniel Herschlag
doi:10.1038/nchembio0809-516
The scope of enzymology has expanded rapidly over the last century, from an early focus on the chemical and catalytic mechanisms of individual enzymes to more recent efforts to understand enzyme action in the context of dynamic, functional biological systems consisting of many interacting enzymes and proteins. Continuing progress in probing the link between molecular structure and function now promises to pave the way for a deeper understanding of the evolution and behavior of the complex biological systems that govern cellular behavior.
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