This collection of Nature Publishing Group articles highlights the various medical conditions that make up what is commonly referred to as Metabolic Syndrome.

Metabolic syndrome affects nearly 50 million Americans — almost one in four American adults. Approximately seven percent of adults in their 20s and about 40 percent of adults over 40 meet the criteria for the syndrome. Metabolic syndrome is a cluster of conditions that occur together and increase the risk for heart disease, stroke and diabetes. Having just one of these conditions — increased blood pressure, elevated insulin levels, excess body fat around the waist or abnormal cholesterol levels — contributes to the risk of serious disease and in combination, the risk is even greater.

There is no accepted or official definition of metabolic syndrome. Whether these risk factors actually can be referred to as a syndrome or not, they represent a growing medical condition involving multiple medical specialties.

This free collection provides valuable insight into this emerging medical and public health epidemic.



American Journal of Hypertension

Angiotensin II Type 1 Receptor Gene Polymorphism Predicts Development of Hypertension and Metabolic Syndrome

Paolo Palatini, Giulio Ceolotto, Francesca Dorigatti, Lucio Mos, Massimo Santonastaso, Paolo Bratti, Italia Papparella, Achille C. Pessina & Andrea Semplicini

doi: 10.1038/ajh.2008.319

American Journal of Hypertension 22, 208-214 (February 2009)

Prevalence of Insulin Resistance and Related Risk Factors for Cardiovascular Disease in Patients With Essential Hypertension

Nereida K.C. Lima, Fahim Abbasi, Cindy Lamendola & Gerald M. Reaven

doi:10.1038/ajh.2008.263

American Journal of Hypertension 22, 106-111 (January 2009)

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European Journal of Clinical Nutrition

Selenium Intake Reduces Serum C3, an Early Marker of Metabolic Syndrome Manifestations, in Healthy Young Adults

B Puchau, M A Zulet, A González de Echávarri, Í Navarro-Blasco & J A Martínez

doi:10.1038/ejcn.2008.48

European Journal of Clinical Nutrition (5 November 2008)

The Effects of Dietary Fibre on C-reactive Protein, an Inflammation Marker Predicting Cardiovascular Disease

B Puchau, M A Zulet, A González de Echávarri, Í Navarro-Blasco & J A Martínez

doi:10.1038/ejcn.2009.8

European Journal of Clinical Nutrition (18 February 2009)

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International Journal of Impotence Research

Increased Erythrocyte Aggregation in Men with Coronary Artery Disease and Erectile Dysfunction

D Justo, N Mashav, Y Arbel, M Kinori, A Steinvil, M Swartzon, B Molat, A Halkin, A Finkelstein, R Heruti, & S Banai

doi:10.1038/ijir.2009.6

International Journal of Impotence Research (26 February 2009)

Surveillance of Cardiovascular Risk Factors for Outpatients in Different Erectile Dysfunction Severity

S-T Chang, C-M Chu, J-T Hsu, P-C Lin, & J-J Shee

doi:10.1038/ijir.2009.1

International Journal of Impotence Research (29 January 2009)

Erectile Dysfunction as a Predictor of Cardiovascular Disease

R A Kloner

doi:10.1038/ijir.2008.20

International Journal of Impotence Research 20, 460-465 (September/October 2008)

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International Journal of Obesity

Adiponectin and Vascular Properties in Obese Patients: Is It a Novel Biomarker of Early Atherosclerosis?

M Shargorodsky, M Boaz, Y Goldberg, Z Matas, D Gavish, A Fux, & N Wolfson

doi:10.1038/ijo.2009.37

International Journal of Obesity (24 February 2009)

Interethnic Differences in the Accuracy of Anthropometric Indicators of Obesity in Screening for High Risk of Coronary Heart Disease

V M Herrera, J P Casas, J J Miranda, P Perel, R Pichardo, A González, J R Sanchez, C Ferreccio, X Aguilera, E Silva, M Oróstegui, L F Gómez, J A Chirinos, J Medina-Lezama, C M Pérez, E Suárez, A P Ortiz, L Rosero, N Schapochnik, Z Ortiz, D Ferrante, M Diaz & L E Bautista on behalf of the investigators of the Latin-American Consortium of Studies in Obesity (LASO)

doi:10.1038/ijo.2009.35

International Journal of Obesity (24 February 2009)

Serum Resistin Correlates with Central Obesity but Weakly with Insulin Resistance in Chinese Children and Adolescents

M Li, A Fisette, X-Y Zhao, J-Y Deng, J Mi & K Cianflone

doi:10.1038/ijo.2009.44

International Journal of Obesity 33, 424-439 (17 March 2009)

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Journal of Human Hypertension

The Metabolic Syndrome in Elderly Individuals Is Associated with Greater Muscular, but Not Elastic Arterial Stiffness, Independent of Low-Grade Inflammation, Endothelial Dysfunction or Insulin Resistance—The Hoorn Study

R M A Henry, I Ferreira, J M Dekker, G Nijpels, P G Scheffer & C D A Stehouwer

doi:10.1038/jhh.2009.8

Journal of Human Hypertension (12 March 2009)

Independent Association of Circulating Resistin with Glomerular Filtration Rate in the Early Stages of Essential Hypertension

K Dimitriadis, C Tsioufis, M Selima, D Tsiachris, A Miliou, A Kasiakogias, E Andrikou, D Tousoulis & C Stefanadis

doi:10.1038/jhh.2009.12

Journal of Human Hypertension (5 March 2009)

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Nature Clinical Practice Endocrinology and Metabolism

Dyslipidemia in Type 2 Diabetes Mellitus

Arshag D Mooradian

doi:10.1038/ncpendmet1066

Nature Clinical Practice Endocrinology and Metabolism 5, 150-159 (March 2009)

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Obesity

The Metabolic Syndrome and Behavioral Correlates in Obese Patients With Binge Eating Disorder

Megan Roehrig, Robin M. Masheb, Marney A. White & Carlos M. Grilo

doi:10.1038/oby.2008.560

Obesity 17, 481-486 (2009)

Cardiac Health in Women With Metabolic Syndrome: Clinical Aspects and Pathophysiology

Jun Ren & Robert O. Kelley

doi:10.1038/oby.2009.8

Obesity (12 February 2009)

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Prostate Cancer and Prostatic Diseases

Insulin and Free Oestradiol are Independent Risk Factors for Benign Prostatic Hyperplasia

J Hammarsten, J-E Damber, M Karlsson, T Knutson, Ö Ljunggren, C Ohlsson, R Peeker, U Smith & D Mellström

doi:10.1038/pcan.2008.50

Prostate Cancer and Prostatic Diseases (30 September 2008)