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Regenerative rehabilitation is the combination of regenerative biology with approaches for physical medicine. Examples of regenerative rehabilitation include the incorporation of physical activity to promote engraftment of stem cells into muscle tissue and the in vitro use of mechanical stimuli on cultured cells or tissues, as a means to optimize the efficacy of cell therapeutics and tissue engineering technologies. This collection includes content from npj Regenerative Medicine and showcases the advances in technology and bioscaffolds and our understanding of how mechanical forces regulate gene expression, cell fate and cell function to use mechanical forces for regenerative medicine. This collection was coordinated by Associate Editor Dr. Thomas Rando, Guest Editor Dr. Fabrisia Ambrosio, and Managing Editor Dr. Marie-Elizabeth A. Barabas.
The synergy between biological and bioengineering advances is critical to developing novel and impactful translational therapies. However, there currently are few opportunities for regenerative scientists to be exposed to the methodologies commonly employed in the clinic by rehabilitation professionals, and most rehabilitation scientists and clinicians are not exposed to the many advances of regenerative medicine. This disconnect has impeded the pace of progress in the field. The Eighth Annual International Symposium on Regenerative Rehabilitation brought together basic scientists, engineers, and rehabilitation clinicians to present scientifically rigorous and cutting-edge research and clinical management, focusing on new and innovative approaches that combine discoveries in tissue engineering, medical devices, and cellular therapies with rehabilitative protocols.