Deep imaging of live tissue

Watching biological processes in vivo has piqued interest for centuries. But the less-than-transparent nature of some of our favorite models and the need for imaging large volumes at high speed pose fundamental hurdles to in vivo optical imaging. Fortunately, advances in optical imaging techniques have helped overcome some of these challenges, making it possible to visualize processes such as early development in flies, beating of the heart in fish, and neural activity in the rodent brain with high spatial and temporal resolution.

This web collection features recent content from several Nature Research journals that has been selected by the editors at Nature Methods. The research papers and commentaries we highlight cover a representative, but certainly not comprehensive, set of methodological developments that facilitate imaging of biological processes within organisms and tissues. We hope you enjoy browsing this collection.

Image: E. Dewalt, Nature Research; T. Katsuki, D. Grover and R. Greenspan, University of California, San Diego; F. Cutrale and L. Trinh, University of Southern California, Los Angeles; R. Chhetri and P. Keller, Janelia Research Campus. 

Reviews and Comment

Primary Research