For the past decade, the number of molecular targets for approved drugs has been debated. However, if we are to develop predictive methods to identify potential new drug targets, it is important that we establish with confidence the number, characteristics and biological diversity of targets of approved drugs. The perspective article by Overington et al. and accompanying poster provide a comprehensive survey of current drug targets, and a wealth of associated information on the characteristics of target families and the drugs that modulate them.

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What's in a number?


Nature Reviews Drug Discovery 5, 975 (2006)


The molecular pharmacopoeia

John P. Overington, Bissan Al Lazikani and Andrew L. Hopkins

Download a high-resolution PDF of the poster (2,000 KB)


How many drug targets are there?

John P. Overington, Bissan Al-Lazikani and Andrew L. Hopkins


Nature Reviews Drug Discovery 5, 993-996 (2006)