Expanding the CRISPR Toolbox

Starting with the established function of CRISPR-Cas9 to knock out or replace specific genes, this poster explores further applications of this system. It depicts transcriptional regulation with nuclease-inactive Cas9 coupled to transcription factors or to a transcriptional repressor, shows how epigenome editing is achieved with inactive Cas9 fused to histone modifying enzymes, and details how one can introduce specific base changes via fusion to a deaminase.

View the Expanding the CRISPR tool box poster.

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