Cardiovascular ageing

Articles

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  Interventions to promote cardiometabolic health and slow cardiovascular ageing

  Cardiovascular ageing and the atherosclerotic process begin very early in life and progress over decades of exposure to suboptimal metabolic and hormonal risk factors. In this Review, Fontana discusses how various approaches, including calorie restriction, intermittent fasting, regular physical activity, and mindfulness-based stress-reduction exercises, can slow the effects of cardiovascular ageing and promote cardiometabolic health.

  • Luigi Fontana

  Review Article23 May 2018 Nature Reviews Cardiology
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  Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty

  Inflammageing is a chronic, pro-inflammatory state that develops with age and is a risk factor for cardiovascular disease, comorbidities, frailty, and death. In this Review, Ferrucci and Fabbri discuss whether therapies to modulate inflammageing can reduce the age-related decline in health.

  • Luigi Ferrucci
  • Elisa Fabbri

  Review Article31 Jul 2018 Nature Reviews Cardiology
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  Mitochondrial quality control mechanisms as molecular targets in cardiac ageing

  Alterations in mitochondrial function, which are amplified by defective mitochondrial quality control (MQC) mechanisms, are major contributing factors to cardiac senescence. In this Review, the authors discuss the mechanisms linking defective MQC to organelle dysfunction in the context of cardiac ageing and consider how these pathways might be targeted for the prevention and treatment of age-related heart dysfunction.

  • Anna Picca
  • Robert T. Mankowski
  • Christiaan Leeuwenburgh

  Review Article24 Jul 2018 Nature Reviews Cardiology
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  Cardiac ageing: extrinsic and intrinsic factors in cellular renewal and senescence

  Various intrinsic and extrinsic factors influence the balance between cellular renewal and senescence in the ageing heart. In this Review, Gude and colleagues discuss these factors, including environment, lifestyle, genetics and epigenetics, inflammation, and oxidative stress, and how they might be therapeutically targeted.

  • Natalie A. Gude
  • Kathleen M. Broughton
  • Mark A. Sussman

  Review Article27 Jul 2018 Nature Reviews Cardiology
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  Endothelial dysfunction and angiogenesis impairment in the ageing vasculature

  Cellular, molecular, and functional changes occur in the endothelium during ageing. Ungvari and colleagues explore the links between oxidative and nitrative stress and the conserved molecular pathways affecting endothelial dysfunction and impaired angiogenesis during ageing, and also speculate on how these pathological processes might be therapeutically targeted.

  • Zoltan Ungvari
  • Stefano Tarantini
  • Anna Csiszar

  Review Article24 May 2018 Nature Reviews Cardiology

• The reality of getting old

  Life expectancy around the world has increased steadily for nearly 200 years. This Focus Issue of Nature Reviews Cardiology features five insightful Review articles that describe numerous facets of the latest research on cardiovascular ageing.

  • Edward G. Lakatta

  Comment31 Jul 2018 Nature Reviews Cardiology