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Despite a large and growing volume of papers on nanotechnology, commercialization of these technologies has been restricted by the lack of driving applications, and the ability to produce nanotechnologies at scale. This Special Topic addresses the second of these challenges, by examining the state of “nanomanufacturing”, reviewing a commercial success in the field, and introducing processes that have promise for mass production. The topic is being introduced with seven invited papers, with more anticipated in coming months. We hope it will inspire more work on nanomanufacturing, encourage discussion of manufacturability, and illuminate a roadmap for researchers addressing challenges in nanomanufacturing.