Translational genetics

The application of genetic knowledge to benefit human health has never looked more promising. Next-generation sequencing technologies are helping to reveal the links between genomic variants and simple and complex traits; stem cells are being harnessed for use in regenerative medicine; and some gene-based therapies achieving clinical success.

The articles in this series document the many ways in which genetic knowledge is changing medical practice, by facilitating screening tests, by informing diagnoses and drug prescribing and, perhaps before long, by routinely offering personalized health-risk assessments and tailored treatments.