Collection |

Technology for neuroengineering

Modelling and treating diseases of the central and peripheral nervous systems requires far better biomaterials and technology than are currently available.

This Collection is updated when relevant new content is published. Content appears in reverse chronological order. See all Collections from Nature Biomedical Engineering.

Research

  • Nature Biomedical Engineering | Article

    Optoacoustic neuroimaging of mice expressing a genetically encoded calcium indicator allows for rapid, high-resolution, whole-brain 3D snapshots of neuronal calcium activity and haemodynamics.

    • Sven Gottschalk
    • , Oleksiy Degtyaruk
    • , Benedict Mc Larney
    • , Johannes Rebling
    • , Magdalena Anastasia Hutter
    • , Xosé Luís Deán-Ben
    • , Shy Shoham
    •  &  Daniel Razansky
  • Nature Biomedical Engineering | Article

    Focal stimulation of cortical tissue from within a blood vessel via an electrode array mounted on a minimally invasive endovascular stent elicits responses from specific facial muscles and limbs in sheep.

    • Nicholas L. Opie
    • , Sam E. John
    • , Gil S. Rind
    • , Stephen M. Ronayne
    • , Yan T. Wong
    • , Giulia Gerboni
    • , Peter E. Yoo
    • , Timothy J. H. Lovell
    • , Theodore C. M. Scordas
    • , Stefan L. Wilson
    • , Anthony Dornom
    • , Thomas Vale
    • , Terence J. O’Brien
    • , David B. Grayden
    • , Clive N. May
    •  &  Thomas J. Oxley
  • Nature Biomedical Engineering | Article

    Hydrogels made from decellularized human brain tissue facilitate the direct conversion of primary mouse embryonic fibroblasts into induced neuronal cells that lead to therapeutic outcomes after transplantation in an animal model of ischaemic stroke.

    • Yoonhee Jin
    • , Jung Seung Lee
    • , Jin Kim
    • , Sungjin Min
    • , Soohyun Wi
    • , Ji Hea Yu
    • , Gyeong-Eon Chang
    • , Ann-Na Cho
    • , Yeeun Choi
    • , Da-Hee Ahn
    • , Sung-Rae Cho
    • , Eunji Cheong
    • , Yun-Gon Kim
    • , Hyong-Pyo Kim
    • , Yonghwan Kim
    • , Dong Seok Kim
    • , Hyun Woo Kim
    • , Zhejiu Quan
    • , Hoon-Chul Kang
    •  &  Seung-Woo Cho
  • Nature Biomedical Engineering | Article

    The combination of focused ultrasound and virally encoded receptors engineered to be activated by a designer drug enables, on intravenous administration of the drug, the non-invasive activation or inhibition of brain regions in mice, with cell-type and spatiotemporal specificity.

    • Jerzy O. Szablowski
    • , Audrey Lee-Gosselin
    • , Brian Lue
    • , Dina Malounda
    •  &  Mikhail G. Shapiro
  • Nature Biomedical Engineering | Article

    Viral transfection of a mixed nerve with two channelrhodopsins with spectrally distinct activation sensitivities enables, via two-colour stimulation of the nerve, optogenetic control over the activity of opposing muscle pairs in a rat hindlimb.

    • Benjamin E. Maimon
    • , Kaitlyn Sparks
    • , Shriya Srinivasan
    • , Anthony N. Zorzos
    •  &  Hugh M. Herr
  • Nature Biomedical Engineering | Article

    Gene editing of a single gene in the brain of an adult mouse model of fragile X syndrome, achieved via the intracranial injection of a nonviral Cas9 delivery vehicle, rescues mice from the exaggerated repetitive behaviours caused by the disease.

    • Bumwhee Lee
    • , Kunwoo Lee
    • , Shree Panda
    • , Rodrigo Gonzales-Rojas
    • , Anthony Chong
    • , Vladislav Bugay
    • , Hyo Min Park
    • , Robert Brenner
    • , Niren Murthy
    •  &  Hye Young Lee

News & Comment

  • Nature Biomedical Engineering | Editorial

    Modelling diseases of the central and peripheral nervous systems and effectively treating neurological disorders via neuronal manipulation requires far better biomaterials and technology than are currently available.

  • Nature Biomedical Engineering | News & Views

    A technique combining focused ultrasound for opening the blood–brain barrier and virally encoded engineered G-protein-coupled receptors for promoting the expression of a gene targeting excitatory neurons enables the non-invasive stimulation of specific brain regions and cell types in mice.

    • Caroline Menard
    •  &  Scott J. Russo
  • Nature Biomedical Engineering | News & Views

    Design principles for the development of silicon biointerfaces enable the non-genetic, light-controlled modulation of intracellular Ca2+ dynamics, and of cellular excitability in vitro, in tissue slices and in mouse brains.

    • Seongjun Park
    • , James A. Frank
    •  &  Polina Anikeeva
  • Nature Biomedical Engineering | News & Views

    Polymer-coated gold nanoparticles carrying the CRISPR components for knocking out, in the striatum of adult mice with fragile X syndrome, a gene implied in the syndrome’s pathophysiology rescue the mice from the exaggerated repetitive behaviours characteristic of the syndrome’s phenotype.

    • Yamin Li
    • , Zachary Glass
    •  &  Qiaobing Xu
  • Nature Biomedical Engineering | News & Views

    Biopolymer matrices can modulate the transcriptomic profiles of stem-cell-derived neurons in 3D culture to make them resemble cells in specific brain regions, developmental stages and disease conditions.

    • Carsten Werner
  • Nature Biomedical Engineering | News & Views

    Synthetic mammalian cells engineered to synthesize a painkiller in response to volatile spearmint reduce chronic pain in mice and do not seem to elicit adverse effects.

    • Daniel D. Lewis
    •  &  Cheemeng Tan