Focus |

Cell Death, Stem Cell and Immunology

A web focus from Cell Death & Differentiation, Cell Death & Disease and Nature Communications. Recent progress in cell death, stem cell biology and cancer research has created a new paradigm of research direction, shifting from pure analytical approaches toward a more translational one with animals and patients. The purpose of this focus is to cover a variety of important topics in cancer and immunology research under the main theme: "Cell Death, Stem Cell and Immunology."

From Cell Death & Differentiation

From Cell Death & Disease

From Nature Communications

Multifunctional S100 proteins are upregulated in brain injury, but their role in neurodegeneration is not clear. Dmytriyeva and colleagues study in vivomodels of brain trauma and find that the S100A4 protein and its peptide mimetics protect neurons via the interleukin-10 receptor and the Janus kinase (JAK)/STAT pathway.

Article | | Nature Communications

Irradiation treatment for cancer therapy often causes irreparable damage to adult organs. Knox and colleagues study irradiated mouse submandibular salivary glands and find that restoring parasympathetic nerve function with the neurotrophic factor neurturin improves regeneration.

Article | | Nature Communications

The histone methyltransferase Ezh2 is thought to have a dual function both as a tumour suppressor and an oncogene. Using mouse models with Ezh2 gain-of-function, Herrera-Merchanet al. show that Ezh2 expression in HSCs severely compromises hematopoietic function, leading to myeloproliferative disease.

Article | | Nature Communications

Levels of extracellular calcium can increase at sites of infection and inflammation; however, the physiological significance of this has been unclear. This work shows that extracellular calcium acts as a danger signal, triggering the NLRP3 inflammasome via two G protein-coupled receptors.

Article | Open Access | | Nature Communications