Protein dynamics

The past decade has seen a debate grow on the possibility that the motions of enzymes could influence the contribution that quantum mechanical tunnelling makes to their activity. In this focus we highlight differing views on the significance that structural dynamics has on the reactivity of enzymes.



Of polemics and progress p141


Disagreements are common in science and can lead to better understanding, but must be handled carefully.



Good vibrations in enzyme-catalysed reactions pp161 - 168

Sam Hay & Nigel S. Scrutton


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This Perspective discusses contemporary ideas for enzymatic reactions that invoke a role for fast 'promoting' (or 'compressive') motions or vibrations that, in principle, can facilitate enzyme-catalysed reactions. With an emphasis on hydrogen-transfer reactions, experimental, theoretical and computational approaches that have lent evidence to this controversial hypothesis are discussed.

Subject terms: Biochemistry | Catalysis | Chemical biology

Taking Ockham's razor to enzyme dynamics and catalysis pp169 - 176

David R. Glowacki, Jeremy N. Harvey & Adrian J. Mulholland


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Enzyme-catalysed reactions can involve significant quantum tunnelling and show kinetic isotope effects with complex temperature dependences. In this Perspective, reaction dynamics and enzyme catalysis are linked to transition-state-theory frameworks. It is shown that a multi-state model using standard transition-state theory can account for complex experimental data without invoking a role for enzyme dynamics.

Subject terms: Catalysis | Theoretical chemistry | Chemical biology

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