Collection |

Point-of-care devices

To establish wider utility at the point of care, device validation should be carried out within the target population, and in the most appropriate environment and use conditions.

This Collection is updated when relevant new content is published. Content appears in reverse chronological order. See all Collections from Nature Biomedical Engineering.

Research

  • Nature Biomedical Engineering | Article

    An electrical biosensor combining CRISPR–Cas9 and a graphene field-effect transistor detects target genes in purified genomic samples at high sensitivity, within 15 minutes, and without the need for amplification.

    • Reza Hajian
    • , Sarah Balderston
    • , Thanhtra Tran
    • , Tara deBoer
    • , Jessy Etienne
    • , Mandeep Sandhu
    • , Noreen A. Wauford
    • , Jing-Yi Chung
    • , Jolie Nokes
    • , Mitre Athaiya
    • , Jacobo Paredes
    • , Regis Peytavi
    • , Brett Goldsmith
    • , Niren Murthy
    • , Irina M. Conboy
    •  &  Kiana Aran
  • Nature Biomedical Engineering | Perspective

    This Perspective describes the current state of point-of-care sensors for the diagnosis and monitoring of sepsis, and outlines opportunities for their use in improving the care of sepsis patients.

    • B. Reddy Jr
    • , U. Hassan
    • , C. Seymour
    • , D. C. Angus
    • , T. S. Isbell
    • , K. White
    • , W. Weir
    • , L. Yeh
    • , A. Vincent
    •  &  R. Bashir
  • Nature Biomedical Engineering | Article

    An ultrasonic and stretchable device conformal to the skin that captures blood pressure waveforms at deeply embedded arterial and venous sites enables the continuous monitoring of cardiovascular events.

    • Chonghe Wang
    • , Xiaoshi Li
    • , Hongjie Hu
    • , Lin Zhang
    • , Zhenlong Huang
    • , Muyang Lin
    • , Zhuorui Zhang
    • , Zhenan Yin
    • , Brady Huang
    • , Hua Gong
    • , Shubha Bhaskaran
    • , Yue Gu
    • , Mitsutoshi Makihata
    • , Yuxuan Guo
    • , Yusheng Lei
    • , Yimu Chen
    • , Chunfeng Wang
    • , Yang Li
    • , Tianjiao Zhang
    • , Zeyu Chen
    • , Albert P. Pisano
    • , Liangfang Zhang
    • , Qifa Zhou
    •  &  Sheng Xu
  • Nature Biomedical Engineering | Article

    A point-of-care device that can run on a variety of power inputs enables isothermal nucleic acid quantification for the diagnosis of infectious diseases in resource-limited settings with unreliable electrical power supply.

    • Ryan Snodgrass
    • , Andrea Gardner
    • , Aggrey Semeere
    • , Varun Lingaiah Kopparthy
    • , Jens Duru
    • , Toby Maurer
    • , Jeffrey Martin
    • , Ethel Cesarman
    •  &  David Erickson
  • Nature Biomedical Engineering | Article

    A low-cost point-of-care device that uses contrast-enhanced microholography and deep learning accurately detects aggressive lymphomas in patients referred for aspiration and biopsy of enlarged lymph nodes.

    • Hyungsoon Im
    • , Divya Pathania
    • , Philip J. McFarland
    • , Aliyah R. Sohani
    • , Ismail Degani
    • , Matthew Allen
    • , Benjamin Coble
    • , Aoife Kilcoyne
    • , Seonki Hong
    • , Lucas Rohrer
    • , Jeremy S. Abramson
    • , Scott Dryden-Peterson
    • , Lioubov Fexon
    • , Misha Pivovarov
    • , Bruce Chabner
    • , Hakho Lee
    • , Cesar M. Castro
    •  &  Ralph Weissleder
  • Nature Biomedical Engineering | Article

    A portable device enables the automated manufacturing of therapeutic-grade biologics in a few hours and under current good-manufacturing-practice conditions.

    • Rajani Adiga
    • , Mustafa Al-adhami
    • , Abhay Andar
    • , Shayan Borhani
    • , Sheniqua Brown
    • , David Burgenson
    • , Merideth A. Cooper
    • , Sevda Deldari
    • , Douglas D. Frey
    • , Xudong Ge
    • , Hui Guo
    • , Chandrasekhar Gurramkonda
    • , Penny Jensen
    • , Yordan Kostov
    • , William LaCourse
    • , Yang Liu
    • , Antonio Moreira
    • , KarunaSri Mupparapu
    • , Chariz Peñalber-Johnstone
    • , Manohar Pilli
    • , Benjamin Punshon-Smith
    • , Aniruddha Rao
    • , Govind Rao
    • , Priyanka Rauniyar
    • , Sergei Snovida
    • , Kanika Taurani
    • , Dagmawi Tilahun
    • , Leah Tolosa
    • , Michael Tolosa
    • , Kevin Tran
    • , Krishna Vattem
    • , Sudha Veeraraghavan
    • , Brandon Wagner
    • , Joshua Wilhide
    • , David W. Wood
    •  &  Adil Zuber

News & Comment

  • Nature Biomedical Engineering | News & Views

    A wearable ultrasound patch enables the continuous monitoring of cardiovascular performance outside the intensive care unit.

    • Steven R. Steinhubl
    •  &  Eric J. Topol
  • Nature Biomedical Engineering | News & Views

    A lunchbox-sized device for nucleic acid quantification that can be powered by sunlight, a flame or electricity enables the diagnosis of disease in settings with unreliable power supply.

    • Zachary Ballard
    •  &  Aydogan Ozcan
  • Nature Biomedical Engineering | News & Views

    A holographic approach relying on small-molecule chromogens enables a rapid and inexpensive test for the accurate classification of aggressive lymphoma at the point of care.

    • Varun L. Kopparthy
    • , Ryan Snodgrass
    •  &  David Erickson
  • Nature Biomedical Engineering | News & Views

    A microfluidic device for assaying neutrophil motility in blood samples from sepsis patients and a machine-learning algorithm trained with the motility data enable a faster and accurate sepsis diagnosis.

    • Umer Hassan
    • , Enrique Valera
    •  &  Rashid Bashir
  • Nature Biomedical Engineering | News & Views

    A 20 cent centrifuge made of paper and string and operated by hand can separate plasma from blood in about 90 seconds.

    • Meaghan Bond
    •  &  Rebecca Richards-Kortum

Video

  • Nature Biomedical Engineering | Video

    A hand-spun centrifuge made of paper and string can separate plasma from whole blood in less than two minutes, and be used to diagnose malaria and other infectious diseases in areas without laboratory resources or electricity.