Nature Outline |

Corneal repair

The eye is a remarkable organ, and the body makes a lot of effort to keep it clear to allow the best possible vision. When infection, injury or an inherited disease disrupts natural regeneration, this can result in pain, inflammation and potentially loss of vision. This Outline introduces the limbal stem cells that naturally regenerate the surface of the cornea, describes the surgical procedures that can help to regenerate the surface of the eye when it’s damaged and gives a flavour of future research directions.

Nature is pleased to acknowledge financial support from Translational Research Informatics Center (TRI) and Kyoto Prefectural University of Medicine in producing this Outline. The sponsor retains sole responsibility for the following messages.

The Translational Research Informatics Center (TRI) was founded in 2002 as the first data center in Japan to promote academia-originated medical innovation. The Academic Research Organization (ARO) network was established in 2013 by TRI and is now transforming into an Asian ARO network in conjunction with Korea, Taiwan and Singapore. Furthermore, we plan to expand this network globally to Europe and the United States. Ultimately, our aim is to develop an infrastructure to support the launch of global clinical trials of academia-originated medical technology, drugs and instruments and to obtain regulatory approval worldwide. This Nature Outline on cornea regeneration describes one of the leading regenerative medicine treatments promoted by TRI, which contributes to our goal of providing new therapeutic options for a number of intractable diseases.

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For more information, please visit

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