Focus |

Focus on Cycles and Rhythms

Daily rhythms are an integral part of life. This special Focus on 'Cycles and Rhythms' features Reviews and a Perspective that explore the molecular mechanisms that drive oscillatory behaviour and that underlie the generation of metabolic and circadian dynamics.

Content

  • Nature Structural & Molecular Biology | Editorial

    Daily rhythms are a constant part of life. This special Focus issue explores the molecular mechanisms that underlie the generation of circadian dynamics.

  • Nature Structural & Molecular Biology | Perspective

    This Perspective focuses on five distinct regulatory elements that have been recognized as being critical for generating and modulating oscillatory dynamics in time and space, in both natural and synthetic biological networks.

    • Yangxiaolu Cao
    • , Allison Lopatkin
    •  &  Lingchong You
  • Nature Structural & Molecular Biology | Review Article

    In this Review, the authors consider the functions of key clock transcription factors and the epigenetic regulatory mechanisms that direct circadian gene expression in mammalian cells.

    • Romeo Papazyan
    • , Yuxiang Zhang
    •  &  Mitchell A Lazar
  • Nature Structural & Molecular Biology | Review Article

    Clock proteins are controlled by multiple post-translational modifications during the circadian cycle. In this Review, the authors examine how post-translational modifications influence the stability, interactions and activity of mammalian clock proteins and how they contribute to proper clock function or are altered in circadian disorders.

    • Arisa Hirano
    • , Ying-Hui Fu
    •  &  Louis J Ptáček
  • Nature Structural & Molecular Biology | Review Article

    This Review examines the molecular mechanisms underlying the plant circadian clock, highlighting the functions of transcriptional circuits and post-translational regulation in timing and describing how clock components integrate and respond to environmental signals.

    • Maria A Nohales
    •  &  Steve A Kay