Collection |

The Epitranscriptome

A role for DNA modification in gene regulation is well established, but much less is known about how RNA modification affects RNA fate and influences the way genes are expressed. This web collection features articles from various Nature journals that highlight this exciting new research area of ‘epitranscriptomics’.

We hope you will enjoy the read!

 
Illustration by Viktor Koen based on concepts developed for Gidi Rechavi’s group, Sheba Medical Center, Tel Aviv University.

Reviews, News and Comment

  • Nature | Technology Feature

    As researchers open up to the reality of RNA modification, an expanded epitranscriptomics toolbox takes shape.

    • Kelly Rae Chi
  • Nature Reviews Genetics | Review Article

    Although it has been known for decades that RNA is subjected to numerous covalent modifications, there has been a recent surge in interest driven by sequencing-based transcriptome-wide detection methods and the realization that RNA modifications have important roles in diverse biological processes. This Review describes the range of detection strategies for RNA modifications, their particular strengths and limitations, and how responsible and complementary application of these techniques will be required to ensure the quality and interpretability of the rapidly accumulating data sets.

    • Mark Helm
    •  &  Yuri Motorin
  • Nature Reviews Molecular Cell Biology | Opinion

    The chemical modifications and structural features of mRNAs are highly dynamic. Together, they regulate the composition and function of the transcriptome by shaping RNA–protein interactions at different stages of the gene expression process.

    • Cole J.T. Lewis
    • , Tao Pan
    •  &  Auinash Kalsotra
  • Nature | News & Views

    A molecular modification called m6Am has been found to regulate the stability of messenger RNAs in mammalian cells. The mechanism casts fresh light on how reversibly modified RNA bases control the fate of mRNA. See Article p.371

    • David E. Weinberg
    •  &  John D. Gross

Primary Research

  • Nature | Letter

    Methylation at the 6 position of adenosine (m6A) in RNA is rapidly and transiently induced at DNA damage sites in response to ultraviolet irradiation.

    • Yang Xiang
    • , Benoit Laurent
    • , Chih-Hung Hsu
    • , Sigrid Nachtergaele
    • , Zhike Lu
    • , Wanqiang Sheng
    • , Chuanyun Xu
    • , Hao Chen
    • , Jian Ouyang
    • , Siqing Wang
    • , Dominic Ling
    • , Pang-Hung Hsu
    • , Lee Zou
    • , Ashwini Jambhekar
    • , Chuan He
    •  &  Yang Shi
  • Nature | Article

    Fat mass and obesity-associated protein (FTO) preferentially demethylates m6Am, a modified adenosine that, when present at the 5′ end of certain mRNAs, positively influences mRNA stability by preventing DCP2-mediated decapping.

    • Jan Mauer
    • , Xiaobing Luo
    • , Alexandre Blanjoie
    • , Xinfu Jiao
    • , Anya V. Grozhik
    • , Deepak P. Patil
    • , Bastian Linder
    • , Brian F. Pickering
    • , Jean-Jacques Vasseur
    • , Qiuying Chen
    • , Steven S. Gross
    • , Olivier Elemento
    • , Françoise Debart
    • , Megerditch Kiledjian
    •  &  Samie R. Jaffrey
  • Nature | Article

    The methylation of adenosine residues on the long non-coding RNA XIST is essential for X-chromosome transcriptional repression during female mammalian development.

    • Deepak P. Patil
    • , Chun-Kan Chen
    • , Brian F. Pickering
    • , Amy Chow
    • , Constanza Jackson
    • , Mitchell Guttman
    •  &  Samie R. Jaffrey
  • Nature | Letter

    The structure of the METTL3–METTL14 complex, which mediates N6-adenosine methylation of RNA, suggests that the METTL3 subunit is the catalytic core while METTL14 serves to bind RNA.

    • Xiang Wang
    • , Jing Feng
    • , Yuan Xue
    • , Zeyuan Guan
    • , Delin Zhang
    • , Zhu Liu
    • , Zhou Gong
    • , Qiang Wang
    • , Jinbo Huang
    • , Chun Tang
    • , Tingting Zou
    •  &  Ping Yin
  • Nature Microbiology | Article

    Infection with HIV-1 triggers an increase in N6-methyladenosine (m6A) modification of both viral and host mRNAs, which impacts viral replication and nuclear export of viral RNA.

    • Gianluigi Lichinchi
    • , Shang Gao
    • , Yogesh Saletore
    • , Gwendolyn Michelle Gonzalez
    • , Vikas Bansal
    • , Yinsheng Wang
    • , Christopher E. Mason
    •  &  Tariq M. Rana

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