Follicular helper T cells provide help to cognate B cells in germinal centers to boost humoral immunity. Nutt and colleagues generate IL-21–GFP reporter mice to track the fate of follicular helper T cells.
Follicular helper T cells
Follicular helper T cells (TFH) are able to closely interact with B cells to promote the formation of germinal centers (GCs). The stable cognate interaction between TFH and B cells in the GC is mutually beneficial to both cells for their development and function. Specifically, help B cells produce long-lived memory B cells and high-affinity antibodies and, in reciprocation, TFH cells are helped by B cells for further differentiation through cell cognation. This results in effective antibody responses to provide protection against pathogenic microbes. This web focus presents links to related articles from across Springer Nature to provide more background information about these cells.
In lymph nodes, cellular positioning can dictate the immune response. Lund and colleagues show that nematode infection triggers interactions between lymphotoxin-producing B cells and CXCR5+ dendritic cells and CD4+ T cells to initiate T helper type 2 responses.