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25 YEARS OF NF-κB

The transcription factor NF-κB orchestrates many facets that underlie the development and homeostasis of immune system cells and the generation of immune responses. Nature Immunology presents six specially commissioned reviews to mark the 25th anniversary of the discovery of NF-κB.

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Editorial

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Celebrating 25 years of NF-κB p681

doi:10.1038/ni0811-681

Few proteins have had as profound an influence on immunity and biology as the transcription factor NF-κB.


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Overview

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NF-κB is 25 pp683 - 685

David Baltimore

doi:10.1038/ni.2072

NF-κB-mediated inflammatory biology can be formulated as the following five states: latency, induction, response, resolution and pathology. The first four involve carefully tuned molecular processes; pathology is the loss of control.


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Historical Commentary

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The origins of NF-κB pp686 - 688

Ranjan Sen

doi:10.1038/ni.2071


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Reviews

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Hierarchies of NF-κB target-gene regulation pp689 - 694

Stephen T Smale

doi:10.1038/ni.2070


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Crosstalk in NF-κB signaling pathways? pp695 - 708

Andrea Oeckinghaus, Matthew S Hayden & Sankar Ghosh

doi:10.1038/ni.2065



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Inflammation meets cancer, with NF-κB as the matchmaker pp715 - 723

Yinon Ben-Neriah & Michael Karin

doi:10.1038/ni.2060


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Research Highlights

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Research Highlights pp724

doi:10.1038/ni0811-724



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