Focus
25 YEARS OF NF-κB
- Focus issue:
- August 2011 Volume 12, No 8
The transcription factor NF-κB orchestrates many facets that underlie the development and homeostasis of immune system cells and the generation of immune responses. Nature Immunology presents six specially commissioned reviews to mark the 25th anniversary of the discovery of NF-κB.
Editorial
Focus on 25 YEARS OF NF-κB
Celebrating 25 years of NF-κB - p681
doi:10.1038/ni0811-681
Few proteins have had as profound an influence on immunity and biology as the transcription factor NF-κB.
Full Text - Celebrating 25 years of NF-κB | PDF (209 KB) - Celebrating 25 years of NF-κB
Overview
Focus on 25 YEARS OF NF-κB
NF-κB is 25 - pp683 - 685
David Baltimore
doi:10.1038/ni.2072
NF-κB-mediated inflammatory biology can be formulated as the following five states: latency, induction, response, resolution and pathology. The first four involve carefully tuned molecular processes; pathology is the loss of control.
Historical Commentary
Focus on 25 YEARS OF NF-κB
The origins of NF-κB - pp686 - 688
Ranjan Sen
doi:10.1038/ni.2071
Full Text - The origins of NF-κB | PDF (245 KB) - The origins of NF-κB
Reviews
Focus on 25 YEARS OF NF-κB
Hierarchies of NF-κB target-gene regulation - pp689 - 694
Stephen T Smale
doi:10.1038/ni.2070
Abstract - Hierarchies of NF-κB target-gene regulation | Full Text - Hierarchies of NF-κB target-gene regulation | PDF (550 KB) - Hierarchies of NF-κB target-gene regulation
Focus on 25 YEARS OF NF-κB
Crosstalk in NF-κB signaling pathways? - pp695 - 708
Andrea Oeckinghaus, Matthew S Hayden & Sankar Ghosh
doi:10.1038/ni.2065
Abstract - Crosstalk in NF-κB signaling pathways | Full Text - Crosstalk in NF-κB signaling pathways? | PDF (1,321 KB) - Crosstalk in NF-κB signaling pathways?
Focus on 25 YEARS OF NF-κB
Return to homeostasis: downregulation of NF-κB responses - pp709 - 714
Jürgen Ruland
doi:10.1038/ni.2055
Abstract - Return to homeostasis: downregulation of NF-κB responses | Full Text - Return to homeostasis: downregulation of NF-κB responses | PDF (574 KB) - Return to homeostasis: downregulation of NF-κB responses
Focus on 25 YEARS OF NF-κB
Inflammation meets cancer, with NF-κB as the matchmaker - pp715 - 723
Yinon Ben-Neriah & Michael Karin
doi:10.1038/ni.2060
Abstract - Inflammation meets cancer, with NF-κB as the matchmaker | Full Text - Inflammation meets cancer, with NF-κB as the matchmaker | PDF (983 KB) - Inflammation meets cancer, with NF-κB as the matchmaker
Research Highlights
Focus on 25 YEARS OF NF-κB
Research Highlights - pp724
doi:10.1038/ni0811-724
Full Text - Research Highlights | PDF (106 KB) - Research Highlights