Parkinson disease

Reviews & Perspectives

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  Parkinson disease

  Parkinson disease is a common neurodegenerative disorder that is characterized by neuronal loss in the substantia nigra, which causes striatal dopamine deficiency. In this Primer, Poewe et al. discuss the epidemiology, pathophysiology, diagnosis and management of Parkinson disease.

  • Werner Poewe
  • Klaus Seppi
  • Anthony E. Lang

  Primer23 Mar 2017 Nature Reviews Disease Primers
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  The two-century journey of Parkinson disease research

  The year 2017 marks 200 years since James Parkinson'sAn Essay on the Shaking Palsywas published. In this Timeline article, Serge Przedborski provides an overview of the various avenues of research into Parkinson disease that have been pursued over these two centuries to better understand this neurodegenerative disorder.

  • Serge Przedborski

  Timeline17 Mar 2017 Nature Reviews Neuroscience
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  Cognitive decline in Parkinson disease

  Dementia is commonly encountered in advanced stages of Parkinson disease (PD), but evidence is accumulating that cognitive decline can manifest much earlier in the disease course. Aarsland and colleagues review current knowledge regarding cognitive impairment in patients with PD, focusing on cerebrospinal fluid and imaging biomarkers as potential predictors of cognitive decline in this population.

  • Dag Aarsland
  • Byron Creese
  • Clive Ballard

  Review Article3 Mar 2017 Nature Reviews Neurology
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  Precision medicine for disease modification in Parkinson disease

  In this Perspectives article, Espay and colleagues argue that that the adoption of precision medicine in Parkinson disease will require a revision of biomarker development efforts, with the ultimate goal of testing putative disease-modifying interventions in well-defined disease subgroups.

  • Alberto J. Espay
  • Patrik Brundin
  • Anthony E. Lang

  Science and Society20 Jan 2017 Nature Reviews Neurology
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  The psychosis spectrum in Parkinson disease

  The publication of a consensus definition of Parkinson disease (PD) psychosis in 2007 led to a rapid expansion of literature focusing on clinical aspects, mechanisms and treatment. The authors review this literature and discuss the evolving view of PD psychosis, from distinct classes of symptoms to a continuum progressing over the course of PD.

  • Dominic H. ffytche
  • Byron Creese
  • Dag Aarsland

  Review Article20 Jan 2017 Nature Reviews Neurology
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  Advances in markers of prodromal Parkinson disease

  The earliest stages of Parkinson disease (PD) offer the best opportunity to intervene, but detecting early disease is difficult. In this Review, Postuma and Berg provide an overview of established and potential markers of prodromal PD, and consider how these markers can be combined to identify patients who have prodromal PD and could benefit from treatment.

  • Ronald B. Postuma
  • Daniela Berg

  Review Article27 Oct 2016 Nature Reviews Neurology
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  Selective neuronal vulnerability in Parkinson disease

  Lewy pathology (LP) and neuronal death in clinical Parkinson disease (cPD) have been attributed to the simple spread of misfolded α-synuclein. Surmeieret al. show that the pattern of pathology in cPD is not consistent with this simple model, suggesting that cell-autonomous factors also contribute to pathogenesis.

  • D. James Surmeier
  • José A. Obeso
  • Glenda M. Halliday

  Review Article20 Jan 2017 Nature Reviews Neuroscience
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  Non-motor features of Parkinson disease

  Parkinson disease is often characterized as a disorder of movement; however, it is also associated with many non-motor features, some of which appear early in the disease course. In this article, Schapira and colleagues provide an overview of these diverse features and their neurobiological basis.

  • Anthony H.V. Schapira
  • K. Ray Chaudhuri
  • Peter Jenner

  Review Article8 Jun 2017 Nature Reviews Neuroscience

• Long-term effects of exercise and physical therapy in people with Parkinson disease

  Exercise and physical therapy are important adjunct interventions to improve gait and balance impairments in patients with Parkinson disease (PD), as these features are inadequately treated by current pharmacological and surgical treatments. Here, Mak and colleagues discuss the long-term effects of exercise and physical therapy for PD, possible risks, recommendations for clinical practice, and emerging treatment approaches.

  • Margaret K. Mak
  • Irene S. Wong-Yu
  • Chloe L. Chung

  Review Article13 Oct 2017 Nature Reviews Neurology
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  Parkinson's disease — the story of an eponym

  To coincide with the 200th anniversary of the publication of An Essay on the Shaking Palsy by James Parkinson, Goedert and Compston explore the origins of the eponym 'Parkinson's disease'. Although Jean-Martin Charcot is often credited with introducing the name in the 1880s, it can actually be traced back to an 1865 publication by William Rutherford Sanders.

  • Michel Goedert
  • Alastair Compston

  Essay8 Dec 2017 Nature Reviews Neurology