Parkinson disease
Parkinson disease is a neurodegenerative disorder that is clinically diagnosed by its motor features and characterized by loss of dopamine neurons in the substantia nigra (pars compacta), which is thought to start years before clinical symptoms manifest. Understanding the causes and underlying mechanisms of cell loss in this disorder will be crucial to prevent or to halt neuronal loss and disease progression. In recent years, an enormous amount of basic and clinical research has revealed many important molecular and cellular changes associated with this disease.
2017 marks the 200th anniversary since James Parkinson published An Essay on the Shaking Palsy. To mark this event, Nature Reviews Disease Primers, Nature Reviews Neuroscience and Nature Reviews Neurology present this collection of articles about cutting-edge basic and clinical research into Parkinson disease.
Nature Reviews Disease Primers
Each Primer provides a global overview of the field and outlines key open research questions. Primers have a modular structure, covering epidemiology; disease mechanisms; diagnosis, screening and prevention; management; and quality of life. Authored by an international panel of academic scientists, translational researchers and clinicians, new Primers are published every week.
Nature Reviews Neuroscience
Nature Reviews Neuroscience covers the breadth and depth of modern neuroscience and provides an authoritative, accessible, topical and engaging first port of call for scientists who are interested in this field.
Nature Reviews Neurology
Nature Reviews Neurology covers the pathogenesis, diagnosis, treatment and management of diseases and injuries affecting the central and peripheral nervous systems. Basic, translational and clinical aspects of neurological disorders are considered, including discussions of genetics, epidemiology, imaging, drug treatments and surgery. Our content is written by internationally renowned clinical academics and researchers and targeted towards readers in the medical sciences.
