Odor blends contain molecules that activate unique, overlapping populations of sensory neurons (OSNs). Here, by imaging OSN axon terminals, as well as their cell bodies within the olfactory epithelium, the authors find widespread antagonistic interactions in binary and complex odor mixtures.
From Brain to Behaviour
Brittany Cardwell: human behaviour.
Fiona Carr: neurological disease.
Sachin Ranade: systems and computational neuroscience.
Christian Schnell: neurophysiology and neurotechnologies.
Welcome to the Nature Communications Editors’ Highlights webpage, 'From Brain to Behaviour'. Each month our editors select a small number of Articles recently published in Nature Communications that they believe are particularly interesting or important.
The aim is to provide a snapshot of some of the most exciting neuroscience research published at Nature Communications.
Make sure to check the Editors' Highlights page each month for new featured articles.
Anatomically and functionally distinct thalamocortical inputs to primary and secondary mouse whisker somatosensory cortices
The thalamus provides sensory input to the cortex, but many aspects of thalamocortical signaling remain unknown. Here, the authors reveal parallel non-overlapping thalamic pathways with distinct representations of tactile and decision-related information during a goal-directed sensorimotor task.
To investigate the molecular foundation of sporadic Alzheimer’s disease (AD), Beckmann et al. constructed multiscale causal networks on a large human AD multi-omics dataset, detecting AD-associated networks and their top predicted regulator, VGF, with extensive validation in the 5xFAD mouse model.
We can flexibly coordinate our movements with external stimuli, but no circuit-level model exists to explain this ability. Inspired by fundamental concepts in control theory, the authors construct a modular neural circuit that captures human behavior in a wide range of temporal coordination tasks.
Wittmann and colleagues show that not only single outcome events but also the global reward state (GRS) impact learning in macaques; low GRS drives explorative choices. Analyses of macaque BOLD signal reveals that GRS impacts activity in the anterior insula as well as the dorsal raphe nucleus.
Do cortical neurons stably represent stimulus features in different contexts? Here, using calcium imaging, the authors show that texture selectivity of individual neurons is dynamic during reversal learning. For a subclass this is contingent on the associated reward and forecasts the onset of learning.
Neurons with grid firing fields are thought to play important roles in spatial cognition. Here, the authors show that in contrast to assumptions underlying current models and analyses, grid fields are modulated by local head direction; this suggests different mechanisms and new roles for grid firing.
How can rodents make sense of the olfactory environment without supervision? Here, the authors formulate olfactory learning as an integrated Bayesian inference problem, then derive a set of synaptic plasticity rules and neural dynamics that enables near-optimal learning of odor identification.
Living in groups allows animals to decrease defenses, enabling other behaviors, but the mechanisms of safety in numbers are unknown. The authors show that fruit flies regulate freezing behavior as a function of group size and identify motion by others, and neurons that detect it, as key to this process.
Male fruitflies sing a patterned wing song during courtship. Here, the authors show that females sing a distinct song during copulation, which is controlled by sex-specific neurons, depends on seminal fluid from the male accessory gland and modulates latency of female remating with subsequent males.