Collection |

Technology for diagnostics

Accurate diagnostics need technology — from imaging hardware and image reconstruction to machine learning —
to detect markers associated with the cause of disease. Note that technology for the diagnosis of cancer is only included in the Cancer diagnostics collection, and that diagnostics technology for histopathology is only included in the Histopathology collection.

This Collection is updated when relevant new content is published. Content appears in reverse chronological order. See all Collections from Nature Biomedical Engineering.

Research

  • Nature Biomedical Engineering | Article

    An electrical biosensor combining CRISPR–Cas9 and a graphene field-effect transistor detects target genes in purified genomic samples at high sensitivity, within 15 minutes, and without the need for amplification.

    • Reza Hajian
    • , Sarah Balderston
    • , Thanhtra Tran
    • , Tara deBoer
    • , Jessy Etienne
    • , Mandeep Sandhu
    • , Noreen A. Wauford
    • , Jing-Yi Chung
    • , Jolie Nokes
    • , Mitre Athaiya
    • , Jacobo Paredes
    • , Regis Peytavi
    • , Brett Goldsmith
    • , Niren Murthy
    • , Irina M. Conboy
    •  &  Kiana Aran
  • Nature Biomedical Engineering | Perspective

    This Perspective describes the current state of point-of-care sensors for the diagnosis and monitoring of sepsis, and outlines opportunities for their use in improving the care of sepsis patients.

    • B. Reddy Jr
    • , U. Hassan
    • , C. Seymour
    • , D. C. Angus
    • , T. S. Isbell
    • , K. White
    • , W. Weir
    • , L. Yeh
    • , A. Vincent
    •  &  R. Bashir
  • Nature Biomedical Engineering | Article

    Topically applied imaging nanoprobes for the detection of intracellular mRNA expression from connective tissue growth factor enable the detection of hypertrophic scars and keloids in the skin of small live animals and in ex vivo human skin.

    • David C. Yeo
    • , Christian Wiraja
    • , Amy S. Paller
    • , Chad A. Mirkin
    •  &  Chenjie Xu
  • Nature Biomedical Engineering | Article

    A continuous-acquisition method for reducing artefacts caused by the beating heart and other body motions in cardiovascular magnetic resonance imaging reduces the reliance on electrocardiography triggering and breath holds.

    • Anthony G. Christodoulou
    • , Jaime L. Shaw
    • , Christopher Nguyen
    • , Qi Yang
    • , Yibin Xie
    • , Nan Wang
    •  &  Debiao Li
  • Nature Biomedical Engineering | Article

    A microfluidic assay that identifies sepsis from a single droplet of diluted blood by measuring the spontaneous motility of neutrophils showed 97% sensitivity and 98% specificity in two independent patient cohorts.

    • Felix Ellett
    • , Julianne Jorgensen
    • , Anika L. Marand
    • , Yuk Ming Liu
    • , Myriam M. Martinez
    • , Vicki Sein
    • , Kathryn L. Butler
    • , Jarone Lee
    •  &  Daniel Irimia

News & Comment

  • Nature Biomedical Engineering | Editorial

    Accurate diagnostics need technology — from imaging hardware and image reconstruction to machine learning — to detect markers associated with the cause of disease.

  • Nature Biomedical Engineering | News & Views

    A method that separates overlapping cardiovascular dynamics arising from the beating of the heart, respiration and signal relaxation simplifies and quantifies cardiovascular magnetic resonance imaging.

    • Ricardo Otazo
  • Nature Biomedical Engineering | News & Views

    A microfluidic device for assaying neutrophil motility in blood samples from sepsis patients and a machine-learning algorithm trained with the motility data enable a faster and accurate sepsis diagnosis.

    • Umer Hassan
    • , Enrique Valera
    •  &  Rashid Bashir
  • Nature Biomedical Engineering | News & Views

    Topically applied spherical nucleic acids targeting an intracellular mRNA biomarker associated with abnormal scarring enable the fluorescent detection of abnormal scars during wound healing.

    • Ronnie H. Fang
    •  &  Liangfang Zhang
  • Nature Biomedical Engineering | News & Views

    The combination of ultrafast ultrasound and positron emission tomography–computed tomography enables the simultaneous 3D imaging of anatomy and metabolism at high resolution.

    • Mark Dewhirst
  • Nature Biomedical Engineering | News & Views

    Uniform iron oxide nanoparticles with a hydrodynamic diameter of about 12 nm offer high biocompatibility and diagnostic yield as contrast agents for the magnetic resonance imaging of large animals.

    • Ali Yilmaz