Nature Outlook |


Skin is the body’s largest organ and first line of defence against disease and injury. Researchers have been working to unlock skin’s secrets so as to help heal, treat and mimic this essential barrier.

This Nature Outlook is editorially independent. It is produced with third party financial support. About this content.

Features and comment

  • Nature | Outlook

    As a multifaceted organ, skin provides the body with protection from infection and the environment, as well as sensory capabilities.

    • Lauren Gravitz
  • Nature | Outlook

    The skin is the body’s largest organ and has several, diverse functions. As well as being a physical barrier, it has immune and sensory properties.

    • Julie Gould
  • Nature | Outlook

    Each person’s skin carries a unique population of microbes that might help to protect skin from infection, or increase its vulnerability.

    • Emily Sohn
  • Sponsor Feature

    The innovation process in pharmaceutical research is continuously evolving. In the past, companies used to work in a closed model where new ideas and knowledge came mainly within house. This model is no longer sustainable and the pharmaceutical industry is increasingly opening up the innovation model.

More from Nature Research

  • Nature Reviews Microbiology | Review Article

    Our skin is home to millions of bacteria, fungi and viruses that comprise the skin microbiota. In this Review, Byrd and colleagues discuss recent insights into skin microbial communities, including their composition in health and disease, dynamics between species and interactions with the immune system.

    • Allyson L. Byrd
    • , Yasmine Belkaid
    •  &  Julia A. Segre
  • Nature | Letter

    Four transcription factors that specify keratinocyte cell fate, facilitate in vivo reprogramming of wound-resident mesenchymal cells, epithealization and regeneration of skin epithelial tissues in mice.

    • Masakazu Kurita
    • , Toshikazu Araoka
    • , Tomoaki Hishida
    • , David D. O’Keefe
    • , Yuta Takahashi
    • , Akihisa Sakamoto
    • , Masahiro Sakurai
    • , Keiichiro Suzuki
    • , Jun Wu
    • , Mako Yamamoto
    • , Reyna Hernandez-Benitez
    • , Alejandro Ocampo
    • , Pradeep Reddy
    • , Maxim Nikolaievich Shokhirev
    • , Pierre Magistretti
    • , Estrella Núñez Delicado
    • , Hitomi Eto
    • , Kiyonori Harii
    •  &  Juan Carlos Izpisua Belmonte
  • Nature Reviews Microbiology | Review Article

    In this Review, Gilbert and Stephens outline the history of the field of microbiology of the built environment and discuss insights into microbial ecology, adaptation and evolution. They consider the implications of this research, specifically, how it is changing the types of materials we use in buildings and how our built environments affect human health.

    • Jack A. Gilbert
    •  &  Brent Stephens
  • Nature Immunology | News & Views

    The relationship between atopic dermatitis and air pollution has been long debated but has now been connected via the aryl hydrocarbon receptor and its control of skin innervation and the consequent triggering of an itch-scratch response.

    • Kenji Kabashima
    • , Atsushi Otsuka
    •  &  Takashi Nomura
  • Nature Immunology | Article

    There are suspected links between air pollution and atopic dermatitis, but the mechanism has remained unclear. Yamamoto and colleagues demonstrate that air pollutants trigger activation of the aryl hydrocarbon receptor in the skin, hyperinnervation and an itch-scratch cycle that leads to atopic dermatitis.

    • Takanori Hidaka
    • , Eisaku Ogawa
    • , Eri H Kobayashi
    • , Takafumi Suzuki
    • , Ryo Funayama
    • , Takeshi Nagashima
    • , Taku Fujimura
    • , Setsuya Aiba
    • , Keiko Nakayama
    • , Ryuhei Okuyama
    •  &  Masayuki Yamamoto
This Nature Outlook is editorially independent, produced with financial support from a third party. About this content.