This issue focuses on the potential applications of systems biology to biotechnology. Although at this stage, most models of biological systems are rather rudimentary, the proliferation of high-throughput technologies for gathering data on a large scale is spurring efforts to describe and predict the functioning of entire systems applicable to drug discovery, industrial biotechnology and other sectors.
A partnership between biology and engineeringpp1211 - 1214 Roger Brent doi:10.1038/nbt1004-1211 Full text|PDF
(104K)
The impact of systems approaches on biological problems in drug discoverypp1215 - 1217 Leroy Hood
& Roger M Perlmutter doi:10.1038/nbt1004-1215 Full text|PDF
(182K)
Two-dimensional annotation of genomespp1218 - 1219 Bernhard Palsson doi:10.1038/nbt1004-1218 Full text|PDF
(111K)
The evolution of molecular biology into systems biologypp1249 - 1252 Hans V Westerhoff
& Bernhard O Palsson Published online: 06 October 2004|doi:10.1038/nbt1020 Abstract|Full text|PDF
(110K)
Systems biology in drug discoverypp1253 - 1259 Eugene C Butcher, Ellen L Berg
& Eric J Kunkel Published online: 06 October 2004|doi:10.1038/nbt1017 Abstract|Full text|PDF
(438K)
Reviews
Exploiting biological complexity for strain improvement through systems biologypp1261 - 1267 Gregory Stephanopoulos, Hal Alper
& Joel Moxley Published online: 06 October 2004|doi:10.1038/nbt1016 Abstract|Full text|PDF
(511K)
The challenges of modeling mammalian biocomplexitypp1268 - 1274 Jeremy K Nicholson, Elaine Holmes, John C Lindon
& Ian D Wilson Published online: 06 October 2004|doi:10.1038/nbt1015 Abstract|Full text|PDF
(464K)
