The tumour microenvironment

The tumour mass consists not only of a heterogeneous population of cancer cells but also a variety of resident and infiltrating host cells, secreted factors and extracellular matrix proteins, collectively known as the tumour microenvironment. Tumour progression is profoundly influenced by interactions of cancer cells with their environment that ultimately determine whether the primary tumour is eradicated, metastasizes or establishes dormant micrometastases. The tumour microenvironment can also shape therapeutic responses and resistance, justifying the recent impetus to target components of the tumour microenvironment, which is best exemplified by the success of immune checkpoint inhibitors in the clinic.

This Collection of the most recently published articles from Nature Reviews Cancer showcases the diverse aspects of tumour microenvironment research, and we hope it will be a valuable resource to research scientists, clinicians and students interested in this field.

Multifaceted effects of the microenvironment on tumour progression

Daniela F. Quail and Johanna A. Joyce

May 2017

Tumour progression is not only dictated by events within tumour cells, but also by whether the surrounding niche is permissive to growth at all stages of disease. Tumours develop in a complex tissue network to which many different cell types are recruited, and this constitutes the tumour microenvironment (TME). The interactions between cancer cells and cells in the TME can lead to immune evasion, angiogenesis, hypoxia and invasion, all of which can shape tumour progression and response to treatment. This poster illustrates the influence of the TME on cancer progression and metastasis, and the different therapeutic opportunities that interactions between cancer cells and the TME can offer.

The Poster is freely available thanks to support from Fluidigm

The poster content is peer reviewed, editorially independent and the sole responsibility of Macmillan Publishers Limited. View this poster as a high-resolution PDF.