Series |

NSMB 25

We mark the 25th year of NSMB with a special Series of commissioned Reviews that celebrate exciting research uncovering the fundamental principles behind biological processes.

Editorial

  • Nature Structural & Molecular Biology | Editorial

    This January 2018 issue starts the 25th year of NSMB’s journey. We mark the occasion by launching a special series that celebrates the exciting research uncovering the fundamental principles behind biological processes.

Reviews

  • Nature Structural & Molecular Biology | Review Article

    Rossmann and colleagues review the rapid progress in our understanding of the structure of Zika virus, building on previous studies of other flaviviruses such as dengue virus.

    • S. Saif Hasan
    • , Madhumati Sevvana
    • , Richard J. Kuhn
    •  &  Michael G. Rossmann
  • Nature Structural & Molecular Biology | Review Article

    In this Review, the authors discuss recent insights into the mechanism of GPCR signaling provided by structural and biophysical elucidation of receptor interactions with G proteins and arrestins.

    • Daniel Hilger
    • , Matthieu Masureel
    •  &  Brian K. Kobilka
  • Nature Structural & Molecular Biology | Review Article

    Developments in basic RNA biology have spawned RNA-based strategies to generate new types of therapeutics. Judy Lieberman reviews RNA-based drug design and discusses barriers to more widespread applications and possible ways to overcome them.

    • Judy Lieberman
  • Nature Structural & Molecular Biology | Review Article

    Zhou, Gaullier and Luger review insights derived from cutting-edge biophysical and structural approaches applied to the study of nucleosome dynamics and nucleosome-binding factors, with a focus on the experimental advances driving the research.

    • Keda Zhou
    • , Guillaume Gaullier
    •  &  Karolin Luger
  • Nature Structural & Molecular Biology | Review Article

    In this Review, Wiedenheft and colleagues retrace events that led from early endeavours to understand the role of Cas9 in CRISPR-mediated adaptive immunity to current efforts aimed at developing this enzyme for programmable genetic editing.

    • Royce A. Wilkinson
    • , Coleman Martin
    • , Artem A. Nemudryi
    •  &  Blake Wiedenheft