Guidelines for the Management of Hypertension

Hypertension Research

Guidelines for the Management of Hypertension

Home blood pressure-lowering effect of digital therapeutics in hypertension: impact of body weight and salt intake
- Kazuomi Kario
- Naoko Tomitani
- Satoshi Hoshide
Article10 Mar 2023 Hypertension Research
Prevalence of primary aldosteronism in patients with concomitant hypertension and obstructive sleep apnea, baseline data of a cohort
- Mulalibieke Heizhati
- Xiayire Aierken
- Nanfang Li
Article7 Mar 2023 Hypertension Research
Quality is not an act, it is a habit—Aristotle
- Tatsuo Shimosawa
Review Article21 Feb 2023 Hypertension Research
Current topics of frailty in association with hypertension and other medical conditions
- Ayumi Toba
- Joji Ishikawa
Mini Review15 Feb 2023 Hypertension Research
What did we learn from the International Databases on Ambulatory and Home Blood Pressure in Relation to Cardiovascular Outcome?
- Kei Asayama
- Katarzyna Stolarz-Skrzypek
- Jan A. Staessen
Review ArticleOpen Access3 Feb 2023 Hypertension Research
Current status of the rapid decline in renal function due to diabetes mellitus and its associated factors: analysis using the National Database of Health Checkups in Japan
- Makoto Fujii
- Yuko Ohno
- Mai Kabayama
ArticleOpen Access2 Feb 2023 Hypertension Research
The association of BP with cardiovascular outcomes in patients with dipstick proteinuria and preserved kidney function
- Yuta Suzuki
- Hidehiro Kaneko
- Issei Komuro
Article19 Jan 2023 Hypertension Research
Persistence and determinants of blood pressure phenotypes according to office and ambulatory blood pressure measurements in youth
- Fernando Martinez
- Josep Redon
- Empar Lurbe
Article13 Jan 2023 Hypertension Research
Blood pressure per the 2017 ACC/AHA and 2018 ESC/ESH guidelines and heart failure risk: the Suita Study
- Ahmed Arafa
- Yoshihiro Kokubo
- Chisato Izumi
Article6 Jan 2023 Hypertension Research
Blood pressure in heart failure management and prevention

Comparison between patients with and without heart failure regarding blood pressure The association between CV events and SBP is linear in patients without heart failure; however, it becomes J-shaped or inverse linear in those with heart failure. The management of BP, including optimal BP or pharmacotherapy, differs between the two populations. ACEi angiotensin-converting enzyme inhibitors, ARB angiotensin II receptor blockers; ARNi angiotensin receptor-neprilysin inhibitors, BB beta-blockers, BP blood pressure, CV cardiovascular, DASH Dietary Approaches to Stop Hypertension, GDMT guideline-directed medical therapy, HF heart failure, HFrEF heart failure with reduced ejection fraction, MRA mineralocorticoid receptor antagonists, SBP systolic blood pressure, SGLT2i sodium-glucose cotransporter 2 inhibitors.
- Daichi Maeda
- Taishi Dotare
- Tohru Minamino
Review Article5 Jan 2023 Hypertension Research
Status of ambulatory blood pressure monitoring and home blood pressure monitoring for the diagnosis and management of hypertension in the US: an up-to-date review
- Maria Cepeda
- Patrick Pham
- Daichi Shimbo
Review ArticleOpen Access5 Jan 2023 Hypertension Research
New 2019 JSH guidelines and the risk of incident cardiovascular disease: The Suita Study
- Ahmed Arafa
- Rena Kashima
- Yoshihiro Kokubo
Brief Communication23 Dec 2022 Hypertension Research
Accuracy of screening strategies for masked hypertension: a large-scale nationwide study based on home blood pressure monitoring

Accuracy of studied variables to predict masked hypertension in the derivation cohort. OBP – office BP; BMI – body mass index; DBP – diastolic BP; SBP – systolic BP; MH – masked hypertension; ESH – European Society of Hypertension; BSC – Brazilian Society of Cardiology; ACC/AHA – American College of Cardiology/American Heart Association
- Marco A. M. Alves
- Audes D. M. Feitosa
- Wilson Nadruz Jr
Article15 Nov 2022 Hypertension Research
Investigation of the urinary sodium-to-potassium ratio target level based on the recommended dietary intake goals for the Japanese population: The INTERMAP Japan

Our proposition is accomplishing cutoff value of approximately 2 for urinary Na/K ratio would be desirable to meet the DRIs dietary goals of both Na and K simultaneously in middle-aged Japanese men and women accustomed to Japanese dietary habits.
- Ebtehal Salman
- Aya Kadota
- for the INTERMAP Research Group
ArticleOpen Access8 Nov 2022 Hypertension Research
Diastolic dysfunction, hypertrophy and hypertension ventricular-arterial uncoupling treatment

Efficiency of the cardiovascular system could be measured by left ventricular-arterial coupling, left ventricular telesystolic elastance and effective arterial elastance. This study demonstrated that achieving optimal mechanical efficiency measured as ventricular-arterial coupling through antihypertensive treatment is essential to achieving regression of left ventricular hypertrophy and diastolic dysfunction.
- Daniel Piskorz
- Luis Keller
- Paula Citta
Article14 Oct 2022 Hypertension Research
Economic evaluation of new blood pressure target for hypertensive patients in Taiwan according to the 2022 hypertension clinical practice guidelines of the Taiwan society of cardiology: a simulation modeling study
- Chia-Te Liao
- Han Siong Toh
- Carol Strong
Article14 Oct 2022 Hypertension Research
Role of housing in blood pressure control: a review of evidence from the Smart Wellness Housing survey in Japan

Hypertension and cardiovascular diseases are not only lifestyle diseases but also life-environment diseases.
- Wataru Umishio
- Toshiharu Ikaga
- on behalf of the SWH survey group
Review ArticleOpen Access13 Oct 2022 Hypertension Research
The first software as medical device of evidence-based hypertension digital therapeutics for clinical practice

Home BP-guided digital approach to prevent the onset of hypertension and its consequences from prehypertension to severe hypertension. SaMD, software of medical device; CVD, cardiovascular disease
- Kazuomi Kario
- Noriko Harada
- Ayako Okura
Mini Review7 Oct 2022 Hypertension Research
Trends in antihypertensive prescription for pregnant women with hypertension and their peripartum outcomes before and after label and guideline revisions in Japan

This retrospective cohort study using Japanese claims data included 13797 pregnant women with hypertension. The study period was divided into three terms to evaluate the influence of regulatory actions. Significant changes were identified in the trend of prescription proportions of nifedipine and hydralazine, but not in pregnancy outcomes.
- Reina Taguchi
- Daisuke Shigemi
- Hideo Yasunaga
Article15 Sep 2022 Hypertension Research
A personal history of research on hypertension From an encounter with hypertension to the development of hypertension practice based on out-of-clinic blood pressure measurements
- Yutaka Imai
Review ArticleOpen Access8 Sep 2022 Hypertension Research
Time-series analysis of blood pressure changes after the guideline update in 2019 and the coronavirus disease pandemic in 2020 using Japanese longitudinal data
- Michihiro Satoh
- Takahisa Murakami
- Hirohito Metoki
Article20 Jun 2022 Hypertension Research
Hypertensive disorders of pregnancy: definition, management, and out-of-office blood pressure measurement
- Hirohito Metoki
- Noriyuki Iwama
- Taku Obara
Review Article20 Jun 2022 Hypertension Research
Cost-effectiveness of digital therapeutics for essential hypertension
- Akihiro Nomura
- Tomoyuki Tanigawa
- Ataru Igarashi
ArticleOpen Access20 Jun 2022 Hypertension Research
Arterial hypertension - clinical trials update 2022

A review to reiterate the most important clinical findings in hypertension research. AA acetaminophen, ACS acute coronary syndrome, AHF acute heart failure, ARNI angiotensin receptor blocker neprilysin inhibitor, BP blood pressure, CV cardiovascular, RDN renal artery denervation, RR risk reduction, RRR relative risk reduction, SBP systolic blood pressure.
- Felix Götzinger
- Michael Kunz
- Felix Mahfoud
Review Article13 May 2022 Hypertension Research
ECG and CT for the detection of left atrial enlargement in hypertensive individuals—a population-based study
- Emma Julia Petronella Nilsson
- Jørgen Tobias Kühl
- Klaus Fuglsang Kofoed
Article28 Apr 2022 Hypertension Research
Blood pressure management for secondary stroke prevention

Hypertension shows a direct and indirect association with all stroke subtypes; the strongest association is observed between hypertension and SVD (which predisposes to LI and ICH), a modest association is observed with LAA, and an indirect association with NVAF and the development and enlargement of cerebral aneurysms. Direct and indirect association between hypertension and etiology of all stroke subtypes would underline the closest association between stroke and hypertension among vascular risk factors and explain the importance of blood pressure management for secondary stroke prevention.
- Kazuo Kitagawa
Review Article18 Apr 2022 Hypertension Research
Aldosterone breakthrough from a pharmacological perspective

Possible pharmacological perspectives of aldosterone breakthrough. 11βHSD, 11 β-hydroxysteroid dehydrogenase; ACE-i, angiotensin converting enzyme inhibitor; AGT, angiotensinogen; Aldo, aldosterone; Ang I, angiotensin I; Ang II, angiotensin II; ARB, angiotensin II receptor blocker; AT1R, angiotensin II type 1 receptor; CYP11B2, cytochrome P450 family 11 subfamily B member 2; K⁺, potassium ion; MR, mineralocorticoid receptor; RAAS, renin-angiotensin aldosterone system; R-i, renin inhibitor.
- Masaki Mogi
Review Article14 Apr 2022 Hypertension Research
Latest hypertension research to inform clinical practice in Asia
- Kazuomi Kario
- Masaki Mogi
- Satoshi Hoshide
Editorial5 Apr 2022 Hypertension Research
Re-evaluating hypertension in children according to different guidelines: a single-center study

AAP guideline is more sensitive and decisive for BP phenotypes in detecting LVH, especially in normal-weight children ≤ 15 years, while ABPM thresholds defined for children at any age have limites effect.
- Cemaliye Basaran
- Belde Kasap Demir
- Ferhan Elmali
Article1 Apr 2022 Hypertension Research
The impact of pre-existing hypertension and its treatment on outcomes in patients admitted to hospital with COVID-19
- Ewan McFarlane
- Marijke Linschoten
- on Behalf of the CAPACITY-COVID Consortium
ArticleOpen Access29 Mar 2022 Hypertension Research
Dietary salt intake in Japan - past, present, and future
- Takuya Tsuchihashi
Review Article16 Mar 2022 Hypertension Research
Isolated diastolic hypertension is not associated with endothelial dysfunction
- Yiming Han
- Tatsuya Maruhashi
- Yukihito Higashi
Article3 Feb 2022 Hypertension Research
Hypertension, the decline of activities of daily living (ADL) and frailty
- Ken Sugimoto
- Koichi Yamamoto
Review Article26 Jan 2022 Hypertension Research
Relationship between blood pressure repeatedly measured by a wrist-cuff oscillometric wearable blood pressure monitoring device and left ventricular mass index in working hypertensive patients
- Kazuomi Kario
- Naoko Tomitani
- Bryan Williams
Article17 Oct 2021 Hypertension Research
Association of treatment-resistant hypertension defined by home blood pressure monitoring with cardiovascular outcome
- Keisuke Narita
- Satoshi Hoshide
- Kazuomi Kario
Article17 Oct 2021 Hypertension Research
Blood pressure, frailty status, and all-cause mortality in elderly hypertensives; The Nambu Cohort Study
- Taku Inoue
- Mitsuteru Matsuoka
- Hisatomi Arima
ArticleOpen Access15 Oct 2021 Hypertension Research
Comparison of questionnaire responses regarding awareness of Japanese Society of Hypertension guidelines for the management of hypertension between 2014 and 2019 in primary care
- Kazuo Kobayashi
- Nobuo Hatori
- Akira Kanamori
Article12 Jul 2021 Hypertension Research
Why we need a single independent international hypertension clinical practice guideline
- Mohamed Ben-Eltriki
- Alan Cassels
- James M. Wright
CommentOpen Access12 May 2021 Hypertension Research
The impact of the 2020 International Society of Hypertension global hypertension practice guidelines on the prevention and control of hypertension in China
- Gang Li
- Rui Hu
- Xuejiao Zhang
Correspondence6 Apr 2021 Hypertension Research
Blood pressure management in patients receiving renal replacement therapy
- Yoshihiko Kanno
Review Article19 Oct 2020 Hypertension Research
Prediction of incident hypertension with the coronary artery calcium score based on the 2017 ACC/AHA high blood pressure guidelines
- Ki-Chul Sung
- Mi-Yeon Lee
- Alberto Avolio
Article4 Aug 2020 Hypertension Research
Frailty and hypertension in older adults: current understanding and future perspectives
- Pan Liu
- Yun Li
- Lina Ma
Review Article10 Jul 2020 Hypertension Research
Epidemiology of hypertension in Japan: beyond the new 2019 Japanese guidelines
- Takashi Hisamatsu
- Hiroyoshi Segawa
- Katsuyuki Miura
Review Article7 Jul 2020 Hypertension Research
How should we define appropriate patients for percutaneous transluminal renal angioplasty treatment?
- Yoshio Iwashima
- Toshihiko Ishimitsu
Review Article22 Jun 2020 Hypertension Research
Recent advances in the management of secondary hypertension: chronic kidney disease
- Takahiro Masuda
- Daisuke Nagata
Review Article17 Jun 2020 Hypertension Research
Beta blocker rebound phenomenon is important, but we do not know its definition, incidence or optimal prevention strategies
- Goran Koracevic
- Sladjana Micic
- Zaklina Ristic
Review Article7 May 2020 Hypertension Research
Cosyntropin stimulation in adrenal vein sampling improves the judgment of successful adrenal vein catheterization and outcome prediction for primary aldosteronism
- Midori Yatabe
- Kanako Bokuda
- Atsuhiro Ichihara
Article30 Apr 2020 Hypertension Research
Interactions of coronaviruses with ACE2, angiotensin II, and RAS inhibitors—lessons from available evidence and insights into COVID-19
- Hisashi Kai
- Mamiko Kai
Review Article27 Apr 2020 Hypertension Research
Increased arterial stiffness and cardiovascular risk prediction in controlled hypertensive patients with coronary artery disease: post hoc analysis of FMD-J (Flow-mediated Dilation Japan) Study A
- Tatsuya Maruhashi
- Junko Soga
- Yukihito Higashi
Article9 Mar 2020 Hypertension Research
Low blood pressure and cardiovascular events in diabetic patients with coronary artery disease after revascularization: the CREDO-Kyoto registry cohort-1
- Hisashi Kai
- Atsushi Katoh
- on behalf of CREDO-Kyoto Investigators
Article4 Feb 2020 Hypertension Research
Perspectives of patients and physicians regarding hypertensive management from an online survey for excellence: a subanalysis of the PARADOX study by physician categories
- Takuo Yoshida
- Nobuhiro Nishigaki
- Naoyuki Hasebe
ArticleOpen Access29 Jan 2020 Hypertension Research
An evidence-based analysis of managing hypertension with isometric resistance exercise—are the guidelines current?
- Neil A. Smart
- Jeffrey Gow
- Melissa J. Pearson
Review Article22 Nov 2019 Hypertension Research
Practical and personal education of dietary therapy in hypertensive patients
- Takuya Tsuchihashi
Review Article1 Oct 2019 Hypertension Research
Add-on ezetimibe treatment to low-dose statins vs medium-intensity statin monotherapy in coronary artery disease patients with poorly controlled dyslipidemia
- Masashi Sakuma
- Shigeru Toyoda
- Teruo Inoue
Article13 Aug 2019 Hypertension Research
The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2019)
- Satoshi Umemura
- Hisatomi Arima
- Nobuhito Hirawa
Guideline2 Aug 2019 Hypertension Research
Comparison of blood pressure values—self-measured at home, measured at an unattended office, and measured at a conventional attended office
- Kei Asayama
- Takayoshi Ohkubo
- The Japanese Society of Hypertension Working Group on the COmparison of Self-measured home, Automated unattended office and Conventional attended office blood pressure (COSAC) study
Article21 Jun 2019 Hypertension Research
Age-stratified prevalence, treatment status, and associated factors of hypertension among US adults following application of the 2017 ACC/AHA guideline
- Gulam Muhammed Al Kibria
- Amy Nemirovsky
- Brendan Day
Article3 Jun 2019 Hypertension Research
Stage 1 hypertension defined by the 2017 ACC/AHA Hypertension Guidelines and Risk of Cardiovascular Events: a Cohort Study from Northern China
- Chunpeng Ji
- Shouling Wu
- Wei Cui
Article27 May 2019 Hypertension Research
Urinary sodium-to-potassium ratio and intake of sodium and potassium among men and women from multiethnic general populations: the INTERSALT Study
- Toshiyuki Iwahori
- Katsuyuki Miura
- for the INTERSALT Research Group
Article17 Apr 2019 Hypertension Research
Angiotensin-converting enzyme inhibitors versus angiotensin receptor blockers in hypertensive patients with myocardial infarction or heart failure: a systematic review and meta-analysis
- Toshio Ohtsubo
- Rei Shibata
- Hisatomi Arima
Article5 Apr 2019 Hypertension Research
Carvedilol and bisoprolol as initial therapy for adult hypertension without compelling indications
- Takuya Kishi
- Eitaro Fujii
Article5 Apr 2019 Hypertension Research
Features of and preventive measures against hypertension in the young
- Hiroshi Kawabe
- Tatsuhiko Azegami
- Hiroshi Hirose
Review ArticleOpen Access20 Mar 2019 Hypertension Research
Analysis of antihypertensive treatment using real-world Japanese data—the retrospective study of antihypertensives for lowering blood pressure (REAL) study
- Mitsuru Ohishi
- Takuo Yoshida
- Yukio Shimasaki
ArticleOpen Access6 Mar 2019 Hypertension Research
Absolute risk score for stroke, myocardial infarction, and all cardiovascular disease: Japan Arteriosclerosis Longitudinal Study
- Akiko Harada
- Hirotsugu Ueshima
- on behalf of the Japan Arteriosclerosis Longitudinal Study Group
Article13 Feb 2019 Hypertension Research
Association between early-stage chronic kidney disease and reduced choroidal thickness in essential hypertensive patients
- Giuseppe Mulè
- Maria Vadalà
- Santina Cottone
Article10 Jan 2019 Hypertension Research
Stroke risk due to partial white-coat or masked hypertension based on the ACC/AHA guideline’s blood pressure threshold: the Ohasama study
- Michihiro Satoh
- Kei Asayama
- Takayoshi Ohkubo
Correspondence6 Nov 2018 Hypertension Research
Home blood pressure monitoring in pediatric hypertension: the US perspective and a plan for action
- George S. Stergiou
- Angeliki Ntineri
- Alexandra Soldatou
Review Article27 Jul 2018 Hypertension Research
Home sphygmomanometers can help in the control of blood pressure: a nationwide field survey
- Tekin Akpolat
- Mustafa Arici
- Yunus Erdem
ArticleOpen Access19 Mar 2018 Hypertension Research

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