Nature Outlook |


Influenza kills up to 500,000 people annually. The influenza virus mutates to evade our immune system and occasionally changes drastically to become a new subtype that can start a pandemic. A century after Spanish flu killed 50 million people, Nature Outlook: Influenza examines the progress towards stopping this devastating disease.

This Nature Outlook is editorially independent, produced with financial support from a third party. About this content.


Science targets an evasive virus.

Outlook | | Nature

A better understanding of the immune response to influenza is driving development of vaccines that protect against many strains of the virus.

Outlook | | Nature

The rise of environmental resistance to the drugs used to combat flu is a potential disaster — but one that we can avert, argues Josef Järhult.

Outlook | | Nature

Understanding how the influenza virus replicates inside the body is helping researchers develop a wider range of antiviral drugs.

Outlook | | Nature

Farms help to spread influenza but they might be an early warning system for the next human pandemic.

Outlook | | Nature

More from Nature Research

Influenza is an infectious respiratory disease that, in humans, is caused by influenza A and influenza B viruses. This PrimeView highlights some key preventive measures to stop its spread.

PrimeView | | Nature Reviews Disease Primers

IFITM3 encodes an antiviral protein that blocks entry of influenza A virus into cells. Paul Thomas and colleagues report that SNP rs34481144 in the 5′ UTR of IFITM3 is an expression quantitative trait locus for this gene and that the risk allele is associated with lower IFITM3 expression and severe influenza disease.

Article | | Nature Medicine

Antibodies have been engineered to recognize diverse strains of influenza, including both the A and B types of virus that cause human epidemics. Are we moving closer to achieving ‘universal’ protection against all flu strains?

News & Views | | Nature

Influenza is an infectious respiratory disease that, in humans, is caused by influenza A and influenza B viruses. This Primer discusses the biological features of influenza viruses, their effects on human and animal health and the mitigation strategies to reduce the burden of this disease.

Primer | | Nature Reviews Disease Primers

Seasonal influenza viruses continue to cause epidemics each year. In this Review, Petrova and Russell discuss recent advances in understanding the molecular determinants of influenza virus immune escape, sources of evolutionary selection pressure, population dynamics of influenza viruses and prospects for better influenza virus control.

Review Article | | Nature Reviews Microbiology