To achieve the biggest impact, nanotechnology-based strategies developed to manage infectious diseases in resourced-limited settings need to take into account the local context.
Several globally significant infectious diseases are not yet treatable with vaccination; nanomaterials are being investigated to provide new strategies for vaccine development.
This Review outlines the potential applications of nanotechnology-based treatments for infectious diseases, with a specific focus on the progress and challenges in developing nanomedicines against HIV, tuberculosis and malaria.
When developing nanotechnology solutions for global health it is important to be mindful of the ethical, environmental, socio-economical, cultural and legal aspects associated with their deployment.
Sharing protocols with the end-users may allow their flexible implementation to produce nanotechnology solutions for global health challenges that better cater for local needs.
The nanotechnology-enabled mRNA-based vaccine platform recently approved against COVID-19 bears hope for improved vaccine development and trialling capacities in low- and middle-income countries as part of a broader global public health agenda.