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Neurogastroenterology

Neurogastroenterology, the neurology of the gastrointestinal tract, liver, gallbladder and pancreas, encompasses the control of digestion and the gastrointestinal system through the integration of the enteric nervous system (ENS) and the central nervous system. In this article series, Nature Reviews Gastroenterology & Hepatology explores basic, translational and clinical topics in neurogastroenterology, from basic mechanisms and fundamental insights into the ENS to understanding and management of motility and functional gastrointestinal disorders.

Reviews

Defaecation is a coordinated process that requires a morphologically intact gastrointestinal tract and the integration of multiple physiological systems (neuromuscular, hormonal and cognitive). This Review describes the physiology of human defaecation and continence, providing insights into the pathophysiology of defaecation and evacuation disorders.

Review Article | | Nature Reviews Gastroenterology & Hepatology

Enteric glia regulate homeostasis in the enteric nervous system and influence gastrointestinal function. This Review provides an update on enteric glial biology and the underlying mechanisms by which enteric glia regulate gastrointestinal function and disease, with a focus on neuronal and immune interactions.

Review Article | | Nature Reviews Gastroenterology & Hepatology

Although the role of the enteric nervous system in congenital enteric neuropathic disorders is well acknowledged, its role in systemic diseases is less understood. Here, the authors focus on diseases in which the enteric nervous system has so far not been considered to have a major role and on its emerging role in neurodegeneration, cancer and diabetes.

Review Article | | Nature Reviews Gastroenterology & Hepatology

Food addiction is an eating behaviour that reflects alterations in brain–gut–microbiome (BGM) interactions and a shift towards hedonic mechanisms. This Review summarizes the physiology of food addiction in obesity as it relates to BGM interactions and provides insights into treatment targets for food addiction aimed at each level of the BGM axis.

Review Article | | Nature Reviews Gastroenterology & Hepatology

Gastrointestinal dysfunction (including dysphagia and constipation) can occur in Parkinson disease (PD), with evidence that they can arise prior to diagnosis of PD. This Review describes new insights into the mechanisms and pathophysiology of the gastrointestinal involvement of PD, including clinical manifestations.

Review Article | | Nature Reviews Gastroenterology & Hepatology

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