Cardiac regulatory mechanisms

Heart failure is a systemic disease in which neuroendocrine activation, inflammation and metabolic changes can impair cardiac function. In addition, variants in genes encoding sarcomeric proteins can predispose individuals to develop heart failure. The 2022 Gordon Research Conference on cardiac regulatory mechanisms aims to identify novel treatment targets by applying high-resolution approaches to complex cardiac disorders. This Focus issue contains articles commissioned from selected conference speakers, together with some related articles from our archive written by other speakers.

Interior of a cardiomyocyte, depicting microtubules, sarcomeres and mitochondria


Focus articles