Efforts to improve diagnostic criteria and treatment could help the millions of people with this underdiagnosed respiratory condition.
Nature Outlook |
For a disease that is thought to affect more than 250 million people, chronic obstructive pulmonary disease (COPD) has long been overlooked. As prevalence climbs, researchers are working to shed new light on COPD and to meet the growing public-health problem head on.
An imaging biomarker, nerve therapy and other highlights from clinical trials and laboratory studies.
Many people with symptoms of chronic obstructive pulmonary disease don’t meet the criteria for diagnosis. The field is grappling with how to define and treat these patients.
Researchers are beginning to work out the part senescent cells play in the respiratory disease.
Extracellular vesicles released in response to cigarette smoke might trigger chronic obstructive pulmonary disease, but engineered versions could be a treatment.
Many people with chronic obstructive pulmonary disease are given steroids despite a lack of evidence underpinning their use.
A ban on CFCs in the 1980s prompted a rethink of the devices used to deliver respiratory drugs, now new worries and the ongoing problems that some patients have using inhalers are bringing change.
Wildfire pollution can be harmful to those with respiratory conditions, but there is little advice on how to keep safe during these events.
Pneumologist María Victorina López Varela lays bare the scale of work required to prevent and treat COPD in the region.
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The physical, mental, and social impact of COPD in a population-based sample: results from the Longitudinal Aging Study Amsterdam
Patients with early-stage chronic lung disease need holistic support to limit the physical, mental and social impacts of the condition. There is more to chronic obstructive pulmonary disease (COPD) than persistent airflow limitation; systemic effects, including loss of muscle strength and higher risk of heart conditions, mental health and social problems can manifest from the early stages. Frits Franssen at CIRO, the Netherlands, and co-workers interviewed 810 participants aged 55–65 from the Longitudinal Aging Study Amsterdam to investigate the physical, mental and social status of COPD sufferers and compare them with healthy controls. Those with COPD were more likely to walk slower, tire easily and perceive themselves as having poor overall health. Socially, COPD patients were less likely to have long-term partners and felt the need for more emotional support than their healthy peers.
New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries
A genome-wide association study in more than 400,000 individuals identifies 139 new signals for lung function. These variants can predict chronic obstructive pulmonary disease in independent, transancestral cohorts.
Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations
Genome-wide analysis of chronic obstructive pulmonary disease identifies 82 loci, 35 of which are new. Integration of gene expression and genomic annotation data shows enrichment of signals in lung tissue, smooth muscle and several lung cell types.