Special |

Mental health

Worldwide, mental-health problems — such as depression, anxiety and substance-use disorders — are responsible for more years lost to disability than any other health condition is. The toll is exacted not just on the health and well-being of patients, but also on their families and on society around them. This collection brings together different facets of mental-health coverage, from original research to reviews of the latest science to in-depth journalism on public-health issues and first-hand accounts of the experience of mental illness.

News & Comment

  • Nature News | News Feature

    Evidence is mounting that medication for ADHD doesn't make a lasting difference to schoolwork or achievement.

    • Katherine Sharpe
  • Nature News | News Feature

    Research suggests that mental illnesses lie along a spectrum — but the field's latest diagnostic manual still splits them apart.

    • David Adam
  • Nature News | News Feature

    Most people bounce back from trauma — but some never recover. Scientists are trying to work out what underlies the difference.

    • Virginia Hughes
  • Nature News | Comment

    As threats to populations transcend national boundaries, it is crucial that responses to mental-health problems do too, say Pamela Y. Collins and Shekhar Saxena.

    • Pamela Y. Collins
    •  &  Shekhar Saxena
  • Nature News | Comment

    Clinicians and neuroscientists must work together to understand and improve psychological treatments, urge Emily A. Holmes, Michelle G. Craske and Ann M. Graybiel.

    • Emily A. Holmes
    • , Michelle G. Craske
    •  &  Ann M. Graybiel

Research & Reviews

  • Nature | News & Views

    Two genetic regions associated with major depressive disorder have been revealed for the first time, through whole-genome sequencing of a population of Han Chinese women. See Letter p.588

    • Patrick F. Sullivan
  • Nature | News & Views

    Many of us were raised or currently live in an urban environment. A neuroimaging study now reveals how this affects brain function when an individual is faced with a stressful situation. See Letter p.498

    • Daniel P. Kennedy
    •  &  Ralph Adolphs
  • Nature | News & Views

    The largest genome-wide analysis of schizophrenia performed so far has identified more than 100 genetic regions that contribute to disease risk, establishing new leads for understanding this form of mental illness. See Article p.421

    • Jonathan Flint
    •  &  Marcus Munafò
  • Nature | Letter

    Genomic analysis of 5,303 Chinese women with recurrent major depressive disorder (MDD) enables the identification and replication of two genome-wide significant loci contributing to risk of MDD on chromosome 10: one near the SIRT1 gene; the other in an intron of the LHPP gene.

    • CONVERGE consortium
    • , Na Cai
    • , Tim B. Bigdeli
    • , Warren Kretzschmar
    • , Yihan Li
    • , Jieqin Liang
    • , Li Song
    • , Jingchu Hu
    • , Qibin Li
    • , Wei Jin
    • , Zhenfei Hu
    • , Guangbiao Wang
    • , Linmao Wang
    • , Puyi Qian
    • , Yuan Liu
    • , Tao Jiang
    • , Yao Lu
    • , Xiuqing Zhang
    • , Ye Yin
    • , Yingrui Li
    • , Xun Xu
    • , Jingfang Gao
    • , Mark Reimers
    • , Todd Webb
    • , Brien Riley
    • , Silviu Bacanu
    • , Roseann E. Peterson
    • , Yiping Chen
    • , Hui Zhong
    • , Zhengrong Liu
    • , Gang Wang
    • , Jing Sun
    • , Hong Sang
    • , Guoqing Jiang
    • , Xiaoyan Zhou
    • , Yi Li
    • , Yi Li
    • , Wei Zhang
    • , Xueyi Wang
    • , Xiang Fang
    • , Runde Pan
    • , Guodong Miao
    • , Qiwen Zhang
    • , Jian Hu
    • , Fengyu Yu
    • , Bo Du
    • , Wenhua Sang
    • , Keqing Li
    • , Guibing Chen
    • , Min Cai
    • , Lijun Yang
    • , Donglin Yang
    • , Baowei Ha
    • , Xiaohong Hong
    • , Hong Deng
    • , Gongying Li
    • , Kan Li
    • , Yan Song
    • , Shugui Gao
    • , Jinbei Zhang
    • , Zhaoyu Gan
    • , Huaqing Meng
    • , Jiyang Pan
    • , Chengge Gao
    • , Kerang Zhang
    • , Ning Sun
    • , Youhui Li
    • , Qihui Niu
    • , Yutang Zhang
    • , Tieqiao Liu
    • , Chunmei Hu
    • , Zhen Zhang
    • , Luxian Lv
    • , Jicheng Dong
    • , Xiaoping Wang
    • , Ming Tao
    • , Xumei Wang
    • , Jing Xia
    • , Han Rong
    • , Qiang He
    • , Tiebang Liu
    • , Guoping Huang
    • , Qiyi Mei
    • , Zhenming Shen
    • , Ying Liu
    • , Jianhua Shen
    • , Tian Tian
    • , Xiaojuan Liu
    • , Wenyuan Wu
    • , Danhua Gu
    • , Guangyi Fu
    • , Jianguo Shi
    • , Yunchun Chen
    • , Xiangchao Gan
    • , Lanfen Liu
    • , Lina Wang
    • , Fuzhong Yang
    • , Enzhao Cong
    • , Jonathan Marchini
    • , Huanming Yang
    • , Jian Wang
    • , Shenxun Shi
    • , Richard Mott
    • , Qi Xu
    • , Jun Wang
    • , Kenneth S. Kendler
    •  &  Jonathan Flint
  • Nature | Article

    Schizophrenia is a highly heritable genetic disorder, however, identification of specific genetic risk variants has proven difficult because of its complex polygenic nature—a large multi-stage genome-wide association study identifies 128 independent associations in over 100 loci (83 of which are new); key findings include identification of genes involved in glutamergic neurotransmission and support for a link between the immune system and schizophrenia.

    • Schizophrenia Working Group of the Psychiatric Genomics Consortium
    • , Stephan Ripke
    • , Benjamin M. Neale
    • , Aiden Corvin
    • , James T. R. Walters
    • , Kai-How Farh
    • , Peter A. Holmans
    • , Phil Lee
    • , Brendan Bulik-Sullivan
    • , David A. Collier
    • , Hailiang Huang
    • , Tune H. Pers
    • , Ingrid Agartz
    • , Esben Agerbo
    • , Margot Albus
    • , Madeline Alexander
    • , Farooq Amin
    • , Silviu A. Bacanu
    • , Martin Begemann
    • , Richard A. Belliveau Jr
    • , Judit Bene
    • , Sarah E. Bergen
    • , Elizabeth Bevilacqua
    • , Tim B. Bigdeli
    • , Donald W. Black
    • , Richard Bruggeman
    • , Nancy G. Buccola
    • , Randy L. Buckner
    • , William Byerley
    • , Wiepke Cahn
    • , Guiqing Cai
    • , Dominique Campion
    • , Rita M. Cantor
    • , Vaughan J. Carr
    • , Noa Carrera
    • , Stanley V. Catts
    • , Kimberly D. Chambert
    • , Raymond C. K. Chan
    • , Ronald Y. L. Chen
    • , Eric Y. H. Chen
    • , Wei Cheng
    • , Eric F. C. Cheung
    • , Siow Ann Chong
    • , C. Robert Cloninger
    • , David Cohen
    • , Nadine Cohen
    • , Paul Cormican
    • , Nick Craddock
    • , James J. Crowley
    • , David Curtis
    • , Michael Davidson
    • , Kenneth L. Davis
    • , Franziska Degenhardt
    • , Jurgen Del Favero
    • , Ditte Demontis
    • , Dimitris Dikeos
    • , Timothy Dinan
    • , Srdjan Djurovic
    • , Gary Donohoe
    • , Elodie Drapeau
    • , Jubao Duan
    • , Frank Dudbridge
    • , Naser Durmishi
    • , Peter Eichhammer
    • , Johan Eriksson
    • , Valentina Escott-Price
    • , Laurent Essioux
    • , Ayman H. Fanous
    • , Martilias S. Farrell
    • , Josef Frank
    • , Lude Franke
    • , Robert Freedman
    • , Nelson B. Freimer
    • , Marion Friedl
    • , Joseph I. Friedman
    • , Menachem Fromer
    • , Giulio Genovese
    • , Lyudmila Georgieva
    • , Ina Giegling
    • , Paola Giusti-Rodríguez
    • , Stephanie Godard
    • , Jacqueline I. Goldstein
    • , Vera Golimbet
    • , Srihari Gopal
    • , Jacob Gratten
    • , Lieuwe de Haan
    • , Christian Hammer
    • , Marian L. Hamshere
    • , Mark Hansen
    • , Thomas Hansen
    • , Vahram Haroutunian
    • , Annette M. Hartmann
    • , Frans A. Henskens
    • , Stefan Herms
    • , Joel N. Hirschhorn
    • , Per Hoffmann
    • , Andrea Hofman
    • , Mads V. Hollegaard
    • , David M. Hougaard
    • , Masashi Ikeda
    • , Inge Joa
    • , Antonio Julià
    • , René S. Kahn
    • , Luba Kalaydjieva
    • , Sena Karachanak-Yankova
    • , Juha Karjalainen
    • , David Kavanagh
    • , Matthew C. Keller
    • , James L. Kennedy
    • , Andrey Khrunin
    • , Yunjung Kim
    • , Janis Klovins
    • , James A. Knowles
    • , Bettina Konte
    • , Vaidutis Kucinskas
    • , Zita Ausrele Kucinskiene
    • , Hana Kuzelova-Ptackova
    • , Anna K. Kähler
    • , Claudine Laurent
    • , Jimmy Lee Chee Keong
    • , S. Hong Lee
    • , Sophie E. Legge
    • , Bernard Lerer
    • , Miaoxin Li
    • , Tao Li
    • , Kung-Yee Liang
    • , Jeffrey Lieberman
    • , Svetlana Limborska
    • , Carmel M. Loughland
    • , Jan Lubinski
    • , Jouko Lönnqvist
    • , Milan Macek Jr
    • , Patrik K. E. Magnusson
    • , Brion S. Maher
    • , Wolfgang Maier
    • , Jacques Mallet
    • , Sara Marsal
    • , Manuel Mattheisen
    • , Morten Mattingsdal
    • , Robert W. McCarley
    • , Colm McDonald
    • , Andrew M. McIntosh
    • , Sandra Meier
    • , Carin J. Meijer
    • , Bela Melegh
    • , Ingrid Melle
    • , Raquelle I. Mesholam-Gately
    • , Andres Metspalu
    • , Patricia T. Michie
    • , Lili Milani
    • , Vihra Milanova
    • , Younes Mokrab
    • , Derek W. Morris
    • , Ole Mors
    • , Kieran C. Murphy
    • , Robin M. Murray
    • , Inez Myin-Germeys
    • , Bertram Müller-Myhsok
    • , Mari Nelis
    • , Igor Nenadic
    • , Deborah A. Nertney
    • , Gerald Nestadt
    • , Kristin K. Nicodemus
    • , Liene Nikitina-Zake
    • , Laura Nisenbaum
    • , Annelie Nordin
    • , Eadbhard O’Callaghan
    • , Colm O’Dushlaine
    • , F. Anthony O’Neill
    • , Sang-Yun Oh
    • , Ann Olincy
    • , Line Olsen
    • , Jim Van Os
    • , Christos Pantelis
    • , George N. Papadimitriou
    • , Sergi Papiol
    • , Elena Parkhomenko
    • , Michele T. Pato
    • , Tiina Paunio
    • , Milica Pejovic-Milovancevic
    • , Diana O. Perkins
    • , Olli Pietiläinen
    • , Jonathan Pimm
    • , Andrew J. Pocklington
    • , John Powell
    • , Alkes Price
    • , Ann E. Pulver
    • , Shaun M. Purcell
    • , Digby Quested
    • , Henrik B. Rasmussen
    • , Abraham Reichenberg
    • , Mark A. Reimers
    • , Alexander L. Richards
    • , Joshua L. Roffman
    • , Panos Roussos
    • , Douglas M. Ruderfer
    • , Veikko Salomaa
    • , Alan R. Sanders
    • , Ulrich Schall
    • , Christian R. Schubert
    • , Thomas G. Schulze
    • , Sibylle G. Schwab
    • , Edward M. Scolnick
    • , Rodney J. Scott
    • , Larry J. Seidman
    • , Jianxin Shi
    • , Engilbert Sigurdsson
    • , Teimuraz Silagadze
    • , Jeremy M. Silverman
    • , Kang Sim
    • , Petr Slominsky
    • , Jordan W. Smoller
    • , Hon-Cheong So
    • , ChrisC. A. Spencer
    • , Eli A. Stahl
    • , Hreinn Stefansson
    • , Stacy Steinberg
    • , Elisabeth Stogmann
    • , Richard E. Straub
    • , Eric Strengman
    • , Jana Strohmaier
    • , T. Scott Stroup
    • , Mythily Subramaniam
    • , Jaana Suvisaari
    • , Dragan M. Svrakic
    • , Jin P. Szatkiewicz
    • , Erik Söderman
    • , Srinivas Thirumalai
    • , Draga Toncheva
    • , Sarah Tosato
    • , Juha Veijola
    • , John Waddington
    • , Dermot Walsh
    • , Dai Wang
    • , Qiang Wang
    • , Bradley T. Webb
    • , Mark Weiser
    • , Dieter B. Wildenauer
    • , Nigel M. Williams
    • , Stephanie Williams
    • , Stephanie H. Witt
    • , Aaron R. Wolen
    • , Emily H. M. Wong
    • , Brandon K. Wormley
    • , Hualin Simon Xi
    • , Clement C. Zai
    • , Xuebin Zheng
    • , Fritz Zimprich
    • , Naomi R. Wray
    • , Kari Stefansson
    • , Peter M. Visscher
    • , Wellcome Trust Case-Control Consortium
    • , Rolf Adolfsson
    • , Ole A. Andreassen
    • , Douglas H. R. Blackwood
    • , Elvira Bramon
    • , Joseph D. Buxbaum
    • , Anders D. Børglum
    • , Sven Cichon
    • , Ariel Darvasi
    • , Enrico Domenici
    • , Hannelore Ehrenreich
    • , Tõnu Esko
    • , Pablo V. Gejman
    • , Michael Gill
    • , Hugh Gurling
    • , Christina M. Hultman
    • , Nakao Iwata
    • , Assen V. Jablensky
    • , Erik G. Jönsson
    • , Kenneth S. Kendler
    • , George Kirov
    • , Jo Knight
    • , Todd Lencz
    • , Douglas F. Levinson
    • , Qingqin S. Li
    • , Jianjun Liu
    • , Anil K. Malhotra
    • , Steven A. McCarroll
    • , Andrew McQuillin
    • , Jennifer L. Moran
    • , Preben B. Mortensen
    • , Bryan J. Mowry
    • , Markus M. Nöthen
    • , Roel A. Ophoff
    • , Michael J. Owen
    • , Aarno Palotie
    • , Carlos N. Pato
    • , Tracey L. Petryshen
    • , Danielle Posthuma
    • , Marcella Rietschel
    • , Brien P. Riley
    • , Dan Rujescu
    • , Pak C. Sham
    • , Pamela Sklar
    • , David St Clair
    • , Daniel R. Weinberger
    • , Jens R. Wendland
    • , Thomas Werge
    • , Mark J. Daly
    • , Patrick F. Sullivan
    •  &  Michael C. O’Donovan
  • Nature | Letter

    A prospective longitudinal study identifies the earliest known indicator of social disability in human infancy: decline in attention to others’ eyes in infants who are later diagnosed with autism; the decline is evident already within the first 2 to 6 months of life, which reveals the early unfolding of the disorder but also offers a promising opportunity for the future of early intervention.

    • Warren Jones
    •  &  Ami Klin