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15th Anniversary

Nature Reviews Urology is 15! To celebrate our crystal anniversary, we have curated this Collection of favourites from our archive, recent cutting-edge articles, and commentaries and opinion from throughout our history.

Cutting edge

Machine learning (ML) is revolutionizing and reshaping health care, and computer-based systems can be trained to perform complex tasks in bioinformatics, medical imaging and medical robotics. In this Review, Goldenberg et al. consider ML in the management of prostate cancer, with growing applications in diagnostic imaging, surgical interventions, skills training and assessment, digital pathology and genomics.

Review Article | | Nature Reviews Urology

The penis is a diverse and rapidly evolving structure, much more complex than its fundamental function — sperm transfer — would seem to require. In this Review, experts in the field discuss the drivers of penis evolution, and consider how the penis might be an ideal characteristic on which to focus in studies to link phenotype with genotype.

Review Article | | Nature Reviews Urology

Many of the bacterial components of the female urinary tract have been characterized, but the viral fraction of this community is largely unknown. Here, the authors describe the current knowledge of bacteriophages within the urinary tract and their possible contribution to urinary tract health.

Review Article | | Nature Reviews Urology

This Review by Ricketts and Linehan comprehensively summarizes the findings of The Cancer Genome Atlas analyses of renal cell carcinoma and their clinical implications. The authors highlight unique and shared features of the tumour histological subtypes, their predictive power and their possible utility as therapeutic targets.

Review Article | | Nature Reviews Urology

From the archives

Georgiadis et al. provide a comprehensive description of the available animal and human literature on sexual reward and sexual incentive motivation, highlighting the major points of convergence and divergence across species. They discuss a neural concept of human sexual behavioural control and suggest novel testable hypotheses for future sex research.

Review Article | | Nature Reviews Urology

Gonorrhoea andMycoplasma genitaliuminfections are evolving to be exceedingly difficult to treat or untreatable. Unemo and Jensen provide an overview and discussion of prevalence data, diagnostics, current treatment recommendations and potential future therapies of these infections, highlighting priorities to retain their treatability.

Review Article | | Nature Reviews Urology

New research indicates that the microbiota at many sites in the body, including the urinary tract, might influence urological health. Whiteside et al. review our current knowledge on the microbiome–host relationship and examine its role in the maintenance of urinary homeostasis, its utility as a predictor of the risk of disease and as a basis for the development of novel therapeutic strategies.

Review Article | | Nature Reviews Urology

Comment and opinion

As a field that embraces technology, urology has evolved quickly in the past 15 years and is likely to change at an even greater pace in the next 15. Several approaches and initiatives have the potential to improve patient care, in particular the use of telemedicine, improvements in data analytics and growth of physician collaboratives.

Comment | | Nature Reviews Urology

The future of urology holds promising new technologies but also a challenging increase in urological care needs. To translate emerging technologies and medical advances into use and accommodate the growing demand for urological services, we need strong collaboration with other health-care professionals within urology, other medical specialties and the community that surrounds our profession.

Comment | | Nature Reviews Urology